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  Tuning cellular responses to BMP-2 with material surfaces

Migliorini, E., Valat, A., Picart, C., & Cavalcanti-Adam, E. A. (2016). Tuning cellular responses to BMP-2 with material surfaces. Cytokine & Growth Factor Reviews, 27, 43-54. doi:10.1016/j.cytogfr.2015.11.008.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-46B3-4 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-7DB9-A
Genre: Journal Article

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CytokinGrowthFactorRev_27_2016_43.pdf (Any fulltext), 2MB
 
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 Creators:
Migliorini, Elisa1, Author              
Valat, Anne, Author
Picart, Catherine, Author
Cavalcanti-Adam, Elisabetta Ada1, 2, Author              
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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Free keywords: BMP receptors; BMP-2; Cell adhesion; Growth factor immobilization; Material surface; Signaling
 Abstract: Bone morphogenetic protein 2 (BMP-2) has been known for decades as a strong osteoinductive factor and for clinical applications is combined solely with collagen as carrier material. The growing concerns regarding side effects and the importance of BMP-2 in several developmental and physiological processes have raised the need to improve the design of materials by controlling BMP-2 presentation. Inspired by the natural cell environment, new material surfaces have been engineered and tailored to provide both physical and chemical cues that regulate BMP-2 activity. Here we describe surfaces designed to present BMP-2 to cells in a spatially and temporally controlled manner. This is achieved by trapping BMP-2 using physicochemical interactions, either covalently grafted or combined with other extracellular matrix components. In the near future, we anticipate that material science and biology will integrate and further develop tools for in vitro studies and potentially bring some of them toward in vivo applications.

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Language(s): eng - English
 Dates: 2015-10-132015-11-132015-12-032016-02-01
 Publication Status: Published in print
 Pages: 12
 Publishing info: -
 Table of Contents: -
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Title: Cytokine & Growth Factor Reviews
  Other : Cytokine Growth Factor Rev.
Source Genre: Journal
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Publ. Info: Oxford : Pergamon
Pages: - Volume / Issue: 27 Sequence Number: - Start / End Page: 43 - 54 Identifier: ISSN: 1359-6101
CoNE: https://pure.mpg.de/cone/journals/resource/954927707193