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  The Drosophila melanogaster gene CG4930 encodes a high affinity inhibitor for endonuclease G

Temme, C., Weissbach, R., Lilie, H., Wilson, C., Meinhart, A., Meyer, S., et al. (2009). The Drosophila melanogaster gene CG4930 encodes a high affinity inhibitor for endonuclease G. The Journal of Biological Chemistry, 284(13), 8337-8348. doi:10.1074/jbc.M808319200.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-4F62-E Version Permalink: https://hdl.handle.net/21.11116/0000-0000-DEDF-C
Genre: Journal Article

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JBiolChem_284_2009_8337.pdf (Any fulltext), 567KB
 
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JBiolChem_284_2009_8337_Suppl.pdf (Supplementary material), 590KB
 
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 Creators:
Temme, Claudia, Author
Weissbach, Rebekka, Author
Lilie, Hauke, Author
Wilson, Clive, Author
Meinhart, Anton1, Author           
Meyer, Sylke, Author
Golbik, Ralph, Author
Schlierhorn, Angelika, Author
Wahle, Elmar, Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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 Abstract: Endonuclease G (EndoG) is a mitochondrial enzyme believed to be released during apoptosis to participate in the degradation of nuclear DNA. This paper describes a Drosophila protein, EndoGI, which inhibits EndoG specifically. EndoG and EndoGI associate with subpicomolar affinity, forming a 2:1 complex in which dimeric EndoG is bound by two tandemly repeated homologous domains of monomeric EndoGI. Binding appears to involve the active site of EndoG. EndoGI is present in the cell nucleus at micromolar concentrations. Upon induction of apoptosis, levels of the inhibitor appear to be reduced, and it is relocalized to the cytoplasm. EndoGI, encoded by the predicted open reading frame cg4930, is expressed throughout Drosophila development. Flies homozygous for a hypomorphic EndoGI mutation have a strongly reduced viability, which is modulated by genetic background and diet. We propose that EndoGI protects the cell against low levels of EndoG outside mitochondria.

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Language(s): eng - English
 Dates: 2009-01-052008-10-302009-01-052009-01-072009-03-27
 Publication Status: Issued
 Pages: 12
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1074/jbc.M808319200
URI: http://www.ncbi.nlm.nih.gov/pubmed/19129189
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Title: The Journal of Biological Chemistry
  Other : JBC
Source Genre: Journal
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Publ. Info: Baltimore, etc. : American Society for Biochemistry and Molecular Biology [etc.]
Pages: - Volume / Issue: 284 (13) Sequence Number: - Start / End Page: 8337 - 8348 Identifier: ISSN: 0021-9258
CoNE: https://pure.mpg.de/cone/journals/resource/954925410826_1