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  Survival of Igɑ-Deficient Mature B Cells Requires BAFF-R Function

Levit-Zerdoun, E., Becker, M., Pohlmeyer, R., Wilhelm, I., Maity, P. C., Rajewsky, K., et al. (2016). Survival of Igɑ-Deficient Mature B Cells Requires BAFF-R Function. The Journal of Immunology, 196, 2348-2360. doi:10.4049/jimmunol.1501707.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-AF99-D Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-A5A2-6
Genre: Zeitschriftenartikel

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https://www.jimmunol.org/content/196/5/2348 (Verlagsversion)
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 Urheber:
Levit-Zerdoun, Ella1, Autor
Becker, Martin1, Autor
Pohlmeyer, Roland1, Autor
Wilhelm, Isabel2, Autor
Maity, Palash Chandra1, Autor
Rajewsky, Klaus2, Autor
Reth, Michael1, Autor
Hobeika, Elias1, Autor
Affiliations:
1Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              
2External Organizations, ou_persistent22              

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Schlagwörter: -
 Zusammenfassung: Expression of a functional BCR is essential for the development of mature B cells and has been invoked in the control of their maintenance. To test this maintenance function in a new experimental setting, we used the tamoxifen-inducible mb1-CreERT2 mouse strain to delete or truncate either the mb-1 gene encoding the BCR signaling subunit Igα or the VDJ segment of the IgH (H chain [HC]). In this system, Cre-mediated deletion of the mb-1 gene is accompanied by expression of a GFP reporter. We found that, although the Igα-deficient mature B cells survive for >20 d in vivo, the HC-deficient or Igα tail-truncated B cell population is short-lived, with the HC-deficient cells displaying signs of an unfolded protein response. We also show that Igα-deficient B cells still respond to the prosurvival factor BAFF in culture and require BAFF-R signaling for their in vivo maintenance. These results suggest that, under certain conditions, the loss of the BCR can be tolerated by mature B cells for some time, whereas HC-deficient B cells, potentially generated by aberrant somatic mutations in the germinal center, are rapidly eliminated.

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Sprache(n): eng - English
 Datum: 2016-03-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.4049/jimmunol.1501707
 Art des Abschluß: -

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Titel: The Journal of Immunology
  Andere : J. Immunol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Baltimore, U.S.A. : Williams & Wilkins
Seiten: - Band / Heft: 196 Artikelnummer: - Start- / Endseite: 2348 - 2360 Identifikator: ISSN: 0022-1767
CoNE: https://pure.mpg.de/cone/journals/resource/954925414915_1