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  Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex

Yamahachi, H., Marik, S. A., McManus, J. N., Denk, W., & Gilbert, C. D. (2009). Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex. Neuron, 64(5), 719-729. doi:10.1016/j.neuron.2009.11.026.

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Genre: Journal Article
Alternative Title : Rapid axonal sprouting and pruning accompany functional reorganization in primary visual cortex

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 Creators:
Yamahachi, Homare, Author
Marik, Sally A., Author
McManus, Justin N., Author
Denk, Winfried1, Author              
Gilbert, Charles D., Author
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: sysneuro
 Abstract: The functional architecture of adult cerebral cortex retains a capacity for experience-dependent change. This is seen following focal binocular lesions, which induce rapid changes in receptive field size and position. To follow the dynamics of the circuitry underlying these changes, we imaged the intrinsic long-range horizontal connections within the lesion projection zone (LPZ) in adult macaque primary visual cortex. To image the same axons over time, we combined viral vector-mediated EGFP transfer and two-photon microscopy. The lesion triggered, within the first week, an approximately 2-fold outgrowth of axons toward the center of the LPZ. Over the subsequent month, axonal density declined due to a parallel process of pruning and sprouting but maintained a net increase relative to prelesion levels. The rate of turnover of axonal boutons also increased. The axonal restructuring recapitulates the pattern of exuberance and pruning seen in early development and correlates well with the functional changes following retinal lesions.

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Language(s): eng - English
 Dates: 2009-10-302009-12-092009-12-10
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664623
DOI: 10.1016/j.neuron.2009.11.026
URI: http://www.ncbi.nlm.nih.gov/pubmed/20005827
Other: 7562
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 64 (5) Sequence Number: - Start / End Page: 719 - 729 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565