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  Late-Stage Deoxyfluorination of Alcohols with PhenoFluor

Sladojevich, F., Arlow, S. I., Pingping, T., & Ritter, T. (2013). Late-Stage Deoxyfluorination of Alcohols with PhenoFluor. Journal of the American Chemical Society, 135(7), 2470-2473. doi:10.1021/ja3125405.

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 Creators:
Sladojevich, Filippo 1, Author
Arlow, Sophie I.1, Author
Pingping, Tang1, Author
Ritter, Tobias1, Author              
Affiliations:
1Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St., Cambridge, MA 02138 USA, ou_persistent22              

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Free keywords: MEDICINAL CHEMISTRY; NATURAL-PRODUCTS; FLUORINATION; TRIFLUOROMETHYLATION; HETEROCYCLES; VANCOMYCIN; FLUORIDES; CATALYSIS; REAGENT; AGENT
 Abstract: An operationally simple protocol for the selective deoxyfluorination of structurally complex alcohols is presented. Several fluorinated derivatives of natural products and pharmaceuticals have been prepared to showcase the potential of the method for late-stage diversification and its functional group compatibility. A series of simple guidelines for predicting the selectivity in substrates with multiple alcohols is given.

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Language(s): eng - English
 Dates: 2012-12-222013-02-112013-02-20
 Publication Status: Published in print
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1021/ja3125405
 Degree: -

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Title: Journal of the American Chemical Society
  Other : J. Am. Chem. Soc.
  Abbreviation : JACS
Source Genre: Journal
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Publ. Info: Washington, DC 20036 : Journal of the American Chemistry Society
Pages: 4 Volume / Issue: 135 (7) Sequence Number: - Start / End Page: 2470 - 2473 Identifier: ISSN: 0002-7863
CoNE: https://pure.mpg.de/cone/journals/resource/954925376870