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  Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips

Löffler, F., Schirwitz, C., Wagner, J., Koenig, K., Maerkle, F., Torralba, G., et al. (2012). Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips. Advanced Functional Materials, 22(12), 2503-2508. doi:10.1002/adfm.201103103.

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Datensatz-Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5114-2 Versions-Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5115-F
Genre: Zeitschriftenartikel

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 Urheber:
Löffler, Felix1, Autor              
Schirwitz, Christopher, Autor
Wagner, Jenny, Autor
Koenig, Kai, Autor
Maerkle, Frieder, Autor
Torralba, Gloria, Autor
Hausmann, Michael, Autor
Bischoff, F. Ralf, Autor
Nesterov-Mueller, Alexander, Autor
Breitling, Frank, Autor
Affiliations:
1External Organizations, ou_persistent22              

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Schlagwörter: -
 Zusammenfassung: Biofunctionalization of surfaces in a microarray format has revolutionized biological assay applications. Here, a microarray system based on a microelectronic chip is presented that allows for a versatile combinatorial in situ molecule synthesis with very high density. Successfully demonstrating an application for peptide array synthesis, the method offers a compact approach, high combinatorial freedom, and, due to the intrinsic alignment, high and reproducible precision. Patterning the chip surface with different microparticle types which imbed different monomers, several thousand different molecule types can be simultaneously elongated layer-by-layer by coupling the particle imbedded monomers to the molecules growing on the chip surface. This technique has the potential for a wide application in combinatorial chemistry, as long as the desired monomeric building blocks are compatible with the chemical process.

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 Datum: 2012
 Publikationsstatus: Im Druck publiziert
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: -
 Identifikatoren: ISI: 000304860500006
DOI: 10.1002/adfm.201103103
 Art des Abschluß: -

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Titel: Advanced Functional Materials
  Andere : Adv. Funct. Mater.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: Weinheim : Wiley-VCH Verlag GmbH
Seiten: - Band / Heft: 22 (12) Artikelnummer: - Start- / Endseite: 2503 - 2508 Identifikator: ISSN: 1616-301X