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  Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips

Löffler, F., Schirwitz, C., Wagner, J., Koenig, K., Maerkle, F., Torralba, G., et al. (2012). Biomolecule Arrays Using Functional Combinatorial Particle Patterning on Microchips. Advanced Functional Materials, 22(12), 2503-2508. doi:10.1002/adfm.201103103.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5114-2 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5115-F
Genre: Journal Article

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 Creators:
Löffler, Felix1, Author              
Schirwitz, Christopher, Author
Wagner, Jenny, Author
Koenig, Kai, Author
Maerkle, Frieder, Author
Torralba, Gloria, Author
Hausmann, Michael, Author
Bischoff, F. Ralf, Author
Nesterov-Mueller, Alexander, Author
Breitling, Frank, Author
Affiliations:
1External Organizations, ou_persistent22              

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 Abstract: Biofunctionalization of surfaces in a microarray format has revolutionized biological assay applications. Here, a microarray system based on a microelectronic chip is presented that allows for a versatile combinatorial in situ molecule synthesis with very high density. Successfully demonstrating an application for peptide array synthesis, the method offers a compact approach, high combinatorial freedom, and, due to the intrinsic alignment, high and reproducible precision. Patterning the chip surface with different microparticle types which imbed different monomers, several thousand different molecule types can be simultaneously elongated layer-by-layer by coupling the particle imbedded monomers to the molecules growing on the chip surface. This technique has the potential for a wide application in combinatorial chemistry, as long as the desired monomeric building blocks are compatible with the chemical process.

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 Dates: 2012
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Identifiers: ISI: 000304860500006
DOI: 10.1002/adfm.201103103
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Title: Advanced Functional Materials
  Other : Adv. Funct. Mater.
Source Genre: Journal
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Publ. Info: Weinheim : Wiley-VCH Verlag GmbH
Pages: - Volume / Issue: 22 (12) Sequence Number: - Start / End Page: 2503 - 2508 Identifier: ISSN: 1616-301X