English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Chip printer

Cheng, Y. C., Löffler, F., Koenig, K., Nesterov, A., Doersam, E., & Breitling, F. (2010). Chip printer. In Advanced Research in Physics and Engineering: Proceedings of the 2nd WSEAS International Conference on NANOTECHNOLOGY (pp. 19-22).

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-50FD-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-50FE-D
Genre: Conference Paper

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Cheng, Yun Chien, Author
Löffler, Felix1, Author              
Koenig, Kai, Author
Nesterov, Alexander, Author
Doersam, Edgar, Author
Breitling, Frank, Author
Affiliations:
1External Organizations, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: Lithographic methods allow for the combinatorial synthesis of >50.000 oligonucleotides per cm(2), which revolutionized the field of genomics. High density peptide arrays promise to advance the field of proteomics in a similar way, but until recently were not available. This is mainly due to the monomer-by-monomer repeated consecutive coupling of 20 different amino acids associated with lithography, which adds up to an excessive number of coupling cycles. A combinatorial synthesis based on electrically charged solid amino acid particles resolves this problem. Here we report the manufacturing of a "chip printer" that could be used to consecutively address the different charged particles to a solid support, where, when completed, the whole layer of solid amino acid particles is melted at once. This frees hitherto immobilized amino acids to couple all 20 different amino acids in one single coupling reaction to the support. The method should allow for the synthesis of very high-density peptide arrays.

Details

show
hide
Language(s):
 Dates: 2010
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000276890000001
 Degree: -

Event

show
hide
Title: 2nd WSEAS International Conference on Nanotechnology/5th WSEAS International Conference on Optics Astrophysics-Astronomy /1st WSEAS International Conference Plasma, Fusion, Nuclear Physics
Place of Event: Univ Cambridge, Cambridge, ENGLAND
Start-/End Date: 2010-02-20 - 2010-02-22

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advanced Research in Physics and Engineering: Proceedings of the 2nd WSEAS International Conference on NANOTECHNOLOGY
Source Genre: Proceedings
 Creator(s):
Affiliations:
Publ. Info: -
Pages: - Volume / Issue: - Sequence Number: - Start / End Page: 19 - 22 Identifier: ISBN: 978-960-474-163-2