English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Spike-timing-dependent plasticity in hippocampal CA3 neurons

Astori, S., Pawlak, V., & Köhr, G. (2010). Spike-timing-dependent plasticity in hippocampal CA3 neurons. Journal of Physiology, 588(22), 4475-4488. doi:10.1113/jphysiol.2010.198366.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Spike-timing-dependent plasticity in hippocampal CA3 neurons

Files

show Files
hide Files
:
JPhysiol_588_2010_4475.pdf (Any fulltext), 765KB
 
File Permalink:
-
Name:
JPhysiol_588_2010_4475.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Astori, Simone1, Author           
Pawlak, Verena1, Author           
Köhr, Georg1, Author           
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: -
 Abstract: Synaptic plasticity of different inputs converging onto CA3 pyramidal neurons is central to theories of hippocampal function. The mossy fibre (MF) input to these neurons is thought to exhibit plasticity that is in nearly all aspects fundamentally different from plasticity in other brain regions: in particular, when induced by high frequency presynaptic stimulation, plasticity at these synapses is independent of NMDA receptor (NMDAR) activation and presynaptically expressed. Here, we show that different stimulation protocols that depend on the close timing of MF activity and postsynaptic spikes induce bidirectional plasticity in CA3 neurons in 3-week-old rats. Long-term potentiation (LTP) is observed when an excitatory postsynaptic potential (EPSP), evoked by MF stimulation, precedes a single postsynaptic action potential (AP) or a brief AP burst by 10 ms. Instead, timing-dependent long-term depression (LTD) requires the pairing of a single AP to an EPSP with a delay of 30 ms. The pairing of APs to synaptic activity is required for plasticity induction, since the application of unpaired APs or EPSPs did not alter synaptic strength. Furthermore, our results demonstrate that both timing-dependent LTP and LTD critically depend on the activation of NMDARs. Specifically blocking postsynaptic NMDARs prevents plasticity, demonstrating that NMDARs important to spike-timing-dependent plasticity in CA3 neurons are required at postsynaptic sites. In summary, this study shows that the close timing of APs to MF excitatory synaptic input can alter synaptic efficacy in CA3 neurons in a bidirectional manner.

Details

show
hide
Language(s): eng - English
 Dates: 2010-08-232010-09-202010-09-272010-11-15
 Publication Status: Issued
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664551
DOI: 10.1113/jphysiol.2010.198366
URI: http://www.ncbi.nlm.nih.gov/pubmed/20876200
Other: 7614
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Journal of Physiology
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: London : Cambridge University Press
Pages: - Volume / Issue: 588 (22) Sequence Number: - Start / End Page: 4475 - 4488 Identifier: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693