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  Transplanted embryonic neurons integrate into adult neocortical circuits

Falkner, S., Grade, S., Dimou, L., Conzelmann, K.-K., Bonhoeffer, T., Goetz, M., et al. (2016). Transplanted embryonic neurons integrate into adult neocortical circuits. Nature, 539(7628), 248-253. doi:10.1038/nature20113.

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 Creators:
Falkner, Susanne1, Author           
Grade, Sofia, Author
Dimou, Leda, Author
Conzelmann, Karl-Klaus, Author
Bonhoeffer, Tobias1, Author           
Goetz, Magdalena, Author
Hübener, Mark1, Author           
Affiliations:
1Department: Synapses-Circuits-Plasticity / Bonhoeffer, MPI of Neurobiology, Max Planck Society, ou_1113545              

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Free keywords: MOUSE VISUAL-CORTEX; CORTICAL-NEURONS; STEM-CELLS; PYRAMIDAL NEURONS; RECEPTIVE-FIELDS; IN-VIVO; EXPERIENCE; BRAIN; RECONSTRUCTION; DEGENERATIONScience & Technology - Other Topics;
 Abstract: The ability of the adult mammalian brain to compensate for neuronal loss caused by injury or disease is very limited. Transplantation aims to replace lost neurons, but the extent to which new neurons can integrate into existing circuits is unknown. Here, using chronic in vivo two-photon imaging, we show that embryonic neurons transplanted into the visual cortex of adult mice mature into bona fide pyramidal cells with selective pruning of basal dendrites, achieving adult-like densities of dendritic spines and axonal boutons within 4-8 weeks. Monosynaptic tracing experiments reveal that grafted neurons receive area-specific, afferent inputs matching those of pyramidal neurons in the normal visual cortex, including topographically organized geniculo-cortical connections. Furthermore, stimulus-selective responses refine over the course of many weeks and finally become indistinguishable from those of host neurons. Thus, grafted neurons can integrate with great specificity into neocortical circuits that normally never incorporate new neurons in the adult brain.

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Language(s): eng - English
 Dates: 2016-11-10
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000387318500036
DOI: 10.1038/nature20113
 Degree: -

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Title: Nature
  Abbreviation : Nature
Source Genre: Journal
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Affiliations:
Publ. Info: London : Nature Publishing Group
Pages: - Volume / Issue: 539 (7628) Sequence Number: - Start / End Page: 248 - 253 Identifier: ISSN: 0028-0836
CoNE: https://pure.mpg.de/cone/journals/resource/954925427238