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  Selectivity in a barren landscape: the P450BioI−ACP complex

Cryle, M. (2010). Selectivity in a barren landscape: the P450BioI−ACP complex. Biochemical Society Transactions (London), 38(4), 934-939. doi:10.1042/BST0380934.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-561E-8 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-561F-6
Genre: Journal Article
Alternative Title : Selectivity in a barren landscape: the P450BioI-ACP complex

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 Creators:
Cryle, Max1, Author              
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1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: carrier protein, CYP107H1, cytochrome P450, fatty acid, oxidation, P450BioI
 Abstract: The cytochromes P450 (P450s) are a superfamily of oxidative haemoproteins that are capable of catalysing a vast range of oxidative transformations, including the oxidation of unactivated alkanes, often with high stereo- and regio-selectivity. Fatty acid hydroxylation by P450s is widespread across both bacteria and higher organisms, with the sites of oxidation and specificity of oxidation varying from system to system. Several key examples are discussed in the present article, with the focus on P450BioI (CYP107H1), a biosynthetic P450 found in the biotin operon of Bacillus subtilis. The biosynthetic function of P450BioI is the formation of pimelic acid, a biotin precursor, via a multiple-step oxidative cleavage of long-chain fatty acids. P450BioI is a member of an important subgroup of P450s that accept their substrates not free in solution, but rather presented by a separate carrier protein. Structural characterization of the P450BioI–ACP (acyl-carrier protein) complex has recently been performed, which has revealed the basis for the oxidation of the centre of the fatty acid chain. The P450BioI–ACP structure is the first such P450–carrier protein complex to be characterized structurally, with important implications for other biosynthetically intriguing P450–carrier protein complexes.

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Language(s): eng - English
 Dates: 2010-03-302010-07-262010-08-01
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664569
DOI: 10.1042/BST0380934
URI: http://www.biochemsoctrans.org/content/38/4/934
Other: 7601
 Degree: -

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Title: Biochemical Society Transactions (London)
  Other : Biochem Soc Trans
Source Genre: Journal
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Publ. Info: London : Portland Press.
Pages: - Volume / Issue: 38 (4) Sequence Number: - Start / End Page: 934 - 939 Identifier: ISSN: 0300-5127
CoNE: https://pure.mpg.de/cone/journals/resource/954925507337