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  Long-term GABA administration induces alpha cell-mediated beta-like cell neogenesis.

Ben-Othman, N., Vieira, A., Courtney, M., Record, F., Gjernes, E., Avolio, F., et al. (2017). Long-term GABA administration induces alpha cell-mediated beta-like cell neogenesis. Cell, 168(1-2), 73-85. doi:10.1016/j.cell.2016.11.002.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5A90-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5A94-5
Genre: Journal Article

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 Creators:
Ben-Othman, N., Author
Vieira, A., Author
Courtney, M., Author
Record, F., Author
Gjernes, E., Author
Avolio, F., Author
Hadzic, B., Author
Druelle, N., Author
Napolitano, T., Author
Navarro-Sanz, S., Author
Silvano, S., Author
Al-Hasani, K., Author
Pfeifer, A., Author
Lacas-Gervais, S., Author
Leuckx, G., Author
Marroquí, L., Author
Thévenet, J., Author
Madsen, O. D., Author
Eizirik, D. L., Author
Heimberg, H., Author
Kerr-Conte, J., AuthorPattou, F., AuthorMansouri, A.1, Author              Collombat, P., Author more..
Affiliations:
1Research Group of Molecular Cell Differentiation, MPI for biophysical chemistry, Max Planck Society, ou_578588              

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 Abstract: The recent discovery that genetically modified α cells can regenerate and convert into β-like cells in vivo holds great promise for diabetes research. However, to eventually translate these findings to human, it is crucial to discover compounds with similar activities. Herein, we report the identification of GABA as an inducer of α-to-β-like cell conversion in vivo. This conversion induces α cell replacement mechanisms through the mobilization of duct-lining precursor cells that adopt an α cell identity prior to being converted into β-like cells, solely upon sustained GABA exposure. Importantly, these neo-generated β-like cells are functional and can repeatedly reverse chemically induced diabetes in vivo. Similarly, the treatment of transplanted human islets with GABA results in a loss of α cells and a concomitant increase in β-like cell counts, suggestive of α-to-β-like cell conversion processes also in humans. This newly discovered GABA-induced α cell-mediated β-like cell neogenesis could therefore represent an unprecedented hope toward improved therapies for diabetes.

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Language(s): eng - English
 Dates: 2016-12-012017-01-12
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/j.cell.2016.11.002
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Title: Cell
Source Genre: Journal
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Pages: - Volume / Issue: 168 (1-2) Sequence Number: - Start / End Page: 73 - 85 Identifier: -