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  Central noradrenaline transporter availability in highly obese, non-depressed individuals

Hesse, S., Becker, G.-A., Rullmann, M., Bresch, A., Luthardt, J., Hankir, M. K., et al. (2017). Central noradrenaline transporter availability in highly obese, non-depressed individuals. European Journal of Nuclear Medicine and Molecular Imaging, 44(6), 1056-1064. doi:10.1007/s00259-016-3590-3.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5BCA-5 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-B618-5
Genre: Journal Article

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 Creators:
Hesse, Swen1, 2, Author
Becker, Georg-Alexander1, Author
Rullmann, Michael1, 2, 3, Author              
Bresch, Anke1, Author
Luthardt, Julia1, Author
Hankir, Mohammed K.2, Author
Zientek, Franziska2, Author
Reißig, Georg2, Author
Patt, Marianne1, Author
Arelin, Katrin3, 4, Author              
Lobsien, Donald5, Author
Müller, Ulrich6, Author
Baldofski, S.2, 7, Author
Meyer, Philipp M.1, Author
Blüher, Matthias8, Author
Fasshauer, Mathias2, 8, Author
Fenske, Wiebke K.2, Author
Stumvoll, Michael2, 8, Author
Hilbert, Anja2, 7, Author
Ding, Yu-Shin9, Author
Sabri, Osama1, 2, Author more..
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Clinic for Cognitive Neurology, University of Leipzig, Germany, ou_persistent22              
5Department of Neuroradiology, University of Leipzig, Germany, ou_persistent22              
6Behavioural and Clinical Neuroscience Institute, University of Cambridge, United Kingdom, ou_persistent22              
7Department of Medical Psychology and Medical Sociology, University of Leipzig, Germany, ou_persistent22              
8Department of Internal Medicine, University of Leipzig, Germany, ou_persistent22              
9Department of Radiology, Psychiatry, and Chemistry, New York University School of Medicine, NY, USA, ou_persistent22              

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Free keywords: Noradrenaline; Noradrenaline transporter; PET; PET imaging; Obesity
 Abstract: Purpose The brain noradrenaline (NA) system plays an important role in the central nervous control of energy balance and is thus implicated in the pathogenesis of obesity. The specific processes modulated by this neurotransmitter which lead to obesity and overeating are still a matter of debate. Methods We tested the hypothesis that in vivo NA transporter (NAT) availability is changed in obesity by using positron emission tomography (PET) and S,S-[11C]O-methylreboxetine (MRB) in twenty subjects comprising ten highly obese (body mass index BMI > 35 kg/m2), metabolically healthy, non-depressed individuals and ten non-obese (BMI < 30 kg/m2) healthy controls. Results Overall, we found no significant differences in binding potential (BPND) values between obese and non-obese individuals in the investigated brain regions, including the NAT-rich thalamus (0.40 ± 0.14 vs. 0.41 ± 0.18; p = 0.84) though additional discriminant analysis correctly identified individual group affiliation based on regional BPND in all but one (control) case. Furthermore, inter-regional correlation analyses indicated different BPND patterns between both groups but this did not survive testing for multiple comparions. Conclusions Our data do not find an overall involvement of NAT changes in human obesity. However, preliminary secondary findings of distinct regional and associative patterns warrant further investigation.

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Language(s): eng - English
 Dates: 2017-01-092017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00259-016-3590-3
PMID: 28066877
PMC: PMC5538358
Other: Epub 2017
 Degree: -

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Project name : -
Grant ID : 01EO1001
Funding program : -
Funding organization : IFB Adiposity Diseases, German Federal Ministry of Education and Research (BMBF)

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Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
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Affiliations:
Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: 44 (6) Sequence Number: - Start / End Page: 1056 - 1064 Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624