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  Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3

Rauch, K. S., Hils, M., Lupar, E., Minguet, S., Sigvardsson, M., Rottenberg, M. E., et al. (2016). Id3 Maintains Foxp3 Expression in Regulatory T Cells by Controlling a Transcriptional Network of E47, Spi-B, and SOCS3. Cell Reports, 17, 2827-2836. doi:dx.doi.org/10.1016/j.celrep.2016.11.045.

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Datensatz-Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-B175-C Versions-Permalink: https://hdl.handle.net/21.11116/0000-0008-9AEC-1
Genre: Zeitschriftenartikel

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https://www.sciencedirect.com/science/article/pii/S2211124716316187?via%3Dihub (Verlagsversion)
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 Urheber:
Rauch, Katharina S.1, Autor
Hils, Miriam1, Autor
Lupar, Ekaterina1, Autor
Minguet, Susana1, Autor
Sigvardsson, Mikael1, Autor
Rottenberg, Martin E.1, Autor
Izcue, Ana2, Autor
Schachtrup, Christian1, Autor
Schachtrup, Kristina1, Autor
Affiliations:
1External Organizations, ou_persistent22              
2Max Planck Institute of Immunobiology and Epigenetics, Max Planck Society, 79108 Freiburg, DE, ou_2243640              

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 Zusammenfassung: The transcription factor Foxp3 dominantly controls regulatory T (Treg) cell function, and only its continuous expression guarantees the maintenance of full Treg cell-suppressive capacity. However, transcriptional regulators maintaining Foxp3 transcription are incompletely described. Here, we report that high E47 transcription factor activity in Treg cells resulted in unstable Foxp3 expression. Under homeostatic conditions, Treg cells expressed high levels of the E47 antagonist Id3, thus restricting E47 activity and maintaining Foxp3 expression. In contrast, stimulation of Id3-deficient or E47-overexpressing Treg cells resulted in the loss of Foxp3 expression in a subset of Treg cells in vivo and in vitro. Mechanistic analysis indicated that E47 activated expression of the transcription factor Spi-B and the suppressor of cytokine signaling 3 (SOCS3), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 and E47 controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity.

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Sprache(n): eng - English
 Datum: 2016-12-13
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: dx.doi.org/10.1016/j.celrep.2016.11.045
 Art des Abschluß: -

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Titel: Cell Reports
Genre der Quelle: Zeitschrift
 Urheber:
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Ort, Verlag, Ausgabe: -
Seiten: - Band / Heft: 17 Artikelnummer: - Start- / Endseite: 2827 - 2836 Identifikator: Anderer: 2211-1247
CoNE: https://pure.mpg.de/cone/journals/resource/2211-1247