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  Cell type-specific thalamic innervation in a column of rat vibrissal cortex

Meyer, H.-S., Wimmer, V. C., Hemberger, M., Bruno, R. M., de Kock, C., Frick, A., et al. (2010). Cell type-specific thalamic innervation in a column of rat vibrissal cortex. Cerebral Cortex, 20(10), 2287-2303. doi:10.1093/cercor/bhq069.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5C1D-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5C1E-3
Genre: Journal Article
Alternative Title : Cell type-specific thalamic innervation in a column of rat vibrissal cortex

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 Creators:
Meyer, Hanno-Sebastian1, Author              
Wimmer, Verena C.1, Author              
Hemberger, Mike2, Author              
Bruno, Randy M.1, Author              
de Kock, Christiaan1, Author              
Frick, Andreas1, Author              
Sakmann, Bert1, Author              
Helmstaedter, Moritz1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              

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Free keywords: barrel cortex dendrite domains POm thalamocortical projection VPM
 Abstract: This is the concluding article in a series of 3 studies that investigate the anatomical determinants of thalamocortical (TC) input to excitatory neurons in a cortical column of rat primary somatosensory cortex (S1). We used viral synaptophysin-enhanced green fluorescent protein expression in thalamic neurons and reconstructions of biocytin-labeled cortical neurons in TC slices to quantify the number and distribution of boutons from the ventral posterior medial (VPM) and posteromedial (POm) nuclei potentially innervating dendritic arbors of excitatory neurons located in layers (L)2-6 of a cortical column in rat somatosensory cortex. We found that 1) all types of excitatory neurons potentially receive substantial TC input (90-580 boutons per neuron); 2) pyramidal neurons in L3-L6 receive dual TC input from both VPM and POm that is potentially of equal magnitude for thick-tufted L5 pyramidal neurons (ca. 300 boutons each from VPM and POm); 3) L3, L4, and L5 pyramidal neurons have multiple (2-4) subcellular TC innervation domains that match the dendritic compartments of pyramidal cells; and 4) a subtype of thick-tufted L5 pyramidal neurons has an additional VPM innervation domain in L4. The multiple subcellular TC innervation domains of L5 pyramidal neurons may partly explain their specific action potential patterns observed in vivo. We conclude that the substantial potential TC innervation of all excitatory neuron types in a cortical column constitutes an anatomical basis for the initial near-simultaneous representation of a sensory stimulus in different neuron types.

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Language(s): eng - English
 Dates: 2010-06-092010-10-01
 Publication Status: Published in print
 Pages: 17
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664504
DOI: 10.1093/cercor/bhq069
URI: http://www.ncbi.nlm.nih.gov/pubmed/20534783
Other: 7666
 Degree: -

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 20 (10) Sequence Number: - Start / End Page: 2287 - 2303 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440