English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Comparison of vasopressin and oxytocin expressions in the hypothalamo-neurohypophysial system of patients with chronic heart failure

Sivukhina, E. V., Dolzhikov, A. A., Morozov, I. E., Jirikowski, G. F., & Grinevich, V. (2010). Comparison of vasopressin and oxytocin expressions in the hypothalamo-neurohypophysial system of patients with chronic heart failure. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme, 42(1), 56-60. doi:10.1055/s-0029-1234081.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5DB6-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5DB7-1
Genre: Journal Article
Alternative Title : Comparison of vasopressin and oxytocin expressions in the hypothalamo-neurohypophysial system of patients with chronic heart failure

Files

show Files
hide Files
:
HormMetabRes_42_2010_56.pdf (Any fulltext), 434KB
 
File Permalink:
-
Name:
HormMetabRes_42_2010_56.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, Heidelberg; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Sivukhina, Elena V., Author
Dolzhikov, A. A., Author
Morozov, Iu. E., Author
Jirikowski, Gustav F., Author
Grinevich, Valery1, 2, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Valery Grinevich Group, Max Planck Institute for Medical Research, Max Planck Society, ou_1497746              

Content

show
hide
Free keywords: vasopressin - oxytocin - hypothalamus - chronic heart failure
 Abstract: The hypothalamic nonapeptide vasopressin is a known player in the pathogenesis of chronic heart failure. According to the large body of clinical evidence, vasopressin has an impact on salt and water imbalance, hyponatremia, and subsequent renal insufficiency - the most common and destructive co-morbidity of patients afflicted with chronic heart failure. Despite the well-documented elevated levels of vasopressin in the blood of such patients, its expression in the magnocellular hypothalamic nuclei and transport to the posterior pituitary has not yet been investigated. In addition, the literature almost lacks the information on the contribution of another member of nonapeptide family, oxytocin, in the pathogenesis of this disease. Here we present a postmortem analysis of vasopressin and oxytocin-immunoreactive neurons and their terminals in the posterior pituitary of 8 male patients (53.8+/-9.3 years) who had died from CHF and 9 male controls (54.6+/-11.8 years). In line with previous clinical reports, our study on hypothalami of chronic heart failure patients revealed a significant increase in the relative profile density (+29%) of vasopressin-positive neurons in the hypothalamic supraoptic nucleus. Consistently we found a significant increase in the relative optic density of vasopressin-immunoreactivity in the posterior pituitary (+33%) of these patients. In contrast, the similar analysis applied for oxytocin neurons revealed no statistically significant differences to controls. In conclusion, our study provides the morphological evidence for activation of vasopressin (but not oxytocin) expression and vasopressin transport to the posterior pituitary in patients with chronic heart failure.

Details

show
hide
Language(s): eng - English
 Dates: 2009-04-272009-07-132009-08-112010-01-01
 Publication Status: Published in print
 Pages: 5
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme
  Alternative Title : Horm. Metab. Res.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Stuttgart : Thieme
Pages: - Volume / Issue: 42 (1) Sequence Number: - Start / End Page: 56 - 60 Identifier: ISSN: 0018-5043