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  Simultaneous quantitative MRI mapping of T1, T2* and magnetic susceptibility with multi-echo MP2RAGE

Metere, R., Kober, T., Möller, H. E., & Schäfer, A. (2017). Simultaneous quantitative MRI mapping of T1, T2* and magnetic susceptibility with multi-echo MP2RAGE. PLoS One, 12(1): e0169265. doi:10.1371/journal.pone.0169265.

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 Urheber:
Metere, Riccardo1, Autor           
Kober, Tobias2, 3, Autor
Möller, Harald E.1, Autor           
Schäfer, Andreas1, 4, Autor           
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department of Radiology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Swiss Federal Institute of Technology in Lausanne, Switzerland, ou_persistent22              
4Siemens Sector Healthcare, Erlangen, Germany, ou_persistent22              

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 Zusammenfassung: The knowledge of relaxation times is essential for understanding the biophysical mechanisms underlying contrast in magnetic resonance imaging. Quantitative experiments, while offering major advantages in terms of reproducibility, may benefit from simultaneous acquisitions. In this work, we demonstrate the possibility of simultaneously recording relaxation-time and susceptibility maps with a prototype Multi-Echo (ME) Magnetization-Prepared 2 RApid Gradient Echoes (MP2RAGE) sequence. T1 maps can be obtained using the MP2RAGE sequence, which is relatively insensitive to inhomogeneities of the radio-frequency transmit field, . As an extension, multiple gradient echoes can be acquired in each of the MP2RAGE readout blocks, which permits the calculation of and susceptibility maps. We used computer simulations to explore the effects of the parameters on the precision and accuracy of the mapping. In vivo parameter maps up to 0.6 mm nominal resolution were acquired at 7 T in 19 healthy volunteers. Voxel-by-voxel correlations and the test-retest reproducibility were used to assess the reliability of the results. When using optimized paramenters, T1 maps obtained with ME-MP2RAGE and standard MP2RAGE showed excellent agreement for the whole range of values found in brain tissues. Simultaneously obtained and susceptibility maps were of comparable quality as Fast Low-Angle SHot (FLASH) results. The acquisition times were more favorable for the ME-MP2RAGE (≈ 19 min) sequence as opposed to the sum of MP2RAGE (≈ 12 min) and FLASH (≈ 10 min) acquisitions. Without relevant sacrifice in accuracy, precision or flexibility, the multi-echo version may yield advantages in terms of reduced acquisition time and intrinsic co-registration, provided that an appropriate optimization of the acquisition parameters is performed.

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Sprache(n): eng - English
 Datum: 2016-04-132016-12-142017-01-12
 Publikationsstatus: Online veröffentlicht
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1371/journal.pone.0169265
PMID: 28081157
PMC: PMC5230783
Anderer: eCollection 2017
 Art des Abschluß: -

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Projektname : Ultra-High Field Magnetic Resonance Imaging / HIMR
Grant ID : 316716
Förderprogramm : Funding Programme 7
Förderorganisation : European Commission (EC)
Projektname : -
Grant ID : HA-314
Förderprogramm : -
Förderorganisation : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”

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Titel: PLoS One
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: San Francisco, CA : Public Library of Science
Seiten: - Band / Heft: 12 (1) Artikelnummer: e0169265 Start- / Endseite: - Identifikator: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850