English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Simultaneous quantitative MRI mapping of T1, T2* and magnetic susceptibility with multi-echo MP2RAGE

Metere, R., Kober, T., Möller, H. E., & Schäfer, A. (2017). Simultaneous quantitative MRI mapping of T1, T2* and magnetic susceptibility with multi-echo MP2RAGE. PLoS One, 12(1): e0169265. doi:10.1371/journal.pone.0169265.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5E2F-B Version Permalink: http://hdl.handle.net/21.11116/0000-0004-F411-5
Genre: Journal Article

Files

show Files
hide Files
:
Metere_2017.pdf (Publisher version), 4MB
Name:
Metere_2017.pdf
Description:
-
Visibility:
Public
MIME-Type / Checksum:
application/pdf / [MD5]
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show

Creators

show
hide
 Creators:
Metere, Riccardo1, Author              
Kober, Tobias2, 3, Author
Möller, Harald E.1, Author              
Schäfer, Andreas1, 4, Author              
Affiliations:
1Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634558              
2Department of Radiology, Centre hospitalier universitaire vaudois, Lausanne, Switzerland, ou_persistent22              
3Swiss Federal Institute of Technology in Lausanne, Switzerland, ou_persistent22              
4Siemens Sector Healthcare, Erlangen, Germany, ou_persistent22              

Content

show
hide
Free keywords: -
 Abstract: The knowledge of relaxation times is essential for understanding the biophysical mechanisms underlying contrast in magnetic resonance imaging. Quantitative experiments, while offering major advantages in terms of reproducibility, may benefit from simultaneous acquisitions. In this work, we demonstrate the possibility of simultaneously recording relaxation-time and susceptibility maps with a prototype Multi-Echo (ME) Magnetization-Prepared 2 RApid Gradient Echoes (MP2RAGE) sequence. T1 maps can be obtained using the MP2RAGE sequence, which is relatively insensitive to inhomogeneities of the radio-frequency transmit field, . As an extension, multiple gradient echoes can be acquired in each of the MP2RAGE readout blocks, which permits the calculation of and susceptibility maps. We used computer simulations to explore the effects of the parameters on the precision and accuracy of the mapping. In vivo parameter maps up to 0.6 mm nominal resolution were acquired at 7 T in 19 healthy volunteers. Voxel-by-voxel correlations and the test-retest reproducibility were used to assess the reliability of the results. When using optimized paramenters, T1 maps obtained with ME-MP2RAGE and standard MP2RAGE showed excellent agreement for the whole range of values found in brain tissues. Simultaneously obtained and susceptibility maps were of comparable quality as Fast Low-Angle SHot (FLASH) results. The acquisition times were more favorable for the ME-MP2RAGE (≈ 19 min) sequence as opposed to the sum of MP2RAGE (≈ 12 min) and FLASH (≈ 10 min) acquisitions. Without relevant sacrifice in accuracy, precision or flexibility, the multi-echo version may yield advantages in terms of reduced acquisition time and intrinsic co-registration, provided that an appropriate optimization of the acquisition parameters is performed.

Details

show
hide
Language(s): eng - English
 Dates: 2016-04-132016-12-142017-01-12
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1371/journal.pone.0169265
PMID: 28081157
PMC: PMC5230783
Other: eCollection 2017
 Degree: -

Event

show

Legal Case

show

Project information

show hide
Project name : Ultra-High Field Magnetic Resonance Imaging / HIMR
Grant ID : 316716
Funding program : Funding Programme 7
Funding organization : European Commission (EC)
Project name : -
Grant ID : HA-314
Funding program : -
Funding organization : Helmholtz Alliance “ICEMED—Imaging and Curing Environmental Metabolic Diseases”

Source 1

show
hide
Title: PLoS One
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: San Francisco, CA : Public Library of Science
Pages: - Volume / Issue: 12 (1) Sequence Number: e0169265 Start / End Page: - Identifier: ISSN: 1932-6203
CoNE: https://pure.mpg.de/cone/journals/resource/1000000000277850