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  Test-retest measurements of dopamine D1-type receptors using simultaneous PET-MRI imaging

Kaller, S., Rullmann, M., Patt, M., Becker, G.-A., Luthardt, J., Girbardt, J., et al. (2017). Test-retest measurements of dopamine D1-type receptors using simultaneous PET-MRI imaging. European Journal of Nuclear Medicine and Molecular Imaging, 44(6), 1025-1032. doi:10.1007/s00259-017-3645-0.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-5F07-0 Version Permalink: http://hdl.handle.net/21.11116/0000-0005-1216-E
Genre: Journal Article

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 Creators:
Kaller, Simon1, Author
Rullmann, Michael1, 2, Author              
Patt, Marianne1, Author
Becker, Georg-Alexander1, Author
Luthardt, Julia1, Author
Girbardt, Johanna2, Author
Meyer, Philipp M.1, Author
Werner, Peter1, Author
Barthel, Henryk1, Author
Bresch, Anke1, Author
Fritz, Thomas Hans2, 3, Author              
Hesse, Swen1, 4, Author
Sabri, Osama1, Author
Affiliations:
1Department of Nuclear Medicine, University of Leipzig, Germany, ou_persistent22              
2Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_634549              
3Institute for Psychoacoustics and Electronic Music, Ghent University, Belgium, ou_persistent22              
4Integrated Research and Treatment Center Adiposity Diseases, University of Leipzig, Germany, ou_persistent22              

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Free keywords: PET/MRI; Dopamine; Test–retest; [11C]SCH23390; Dopamine receptor; D1R
 Abstract: Purpose The role of dopamine D1-type receptor (D1R)-expressing neurons in the regulation of motivated behavior and reward prediction has not yet been fully established. As a prerequisite for future research assessing D1-mediated neuronal network regulation using simultaneous PET/MRI and D1R-selective [11C]SCH23390, this study investigated the stability of central D1R measurements between two independent PET/MRI sessions under baseline conditions. Methods Thirteen healthy volunteers (7 female, age 33 ± 13 yrs) underwent 90-min emission scans, each after 90-s bolus injection of 486 ± 16 MBq [11C]SCH23390, on two separate days within 2–4 weeks using a PET/MRI system. Parametric images of D1R distribution volume ratio (DVR) and binding potential (BPND) were generated by a multi-linear reference tissue model with two parameters and the cerebellar cortex as receptor-free reference region. Volume-of-interest (VOI) analysis was performed with manual VOIs drawn on consecutive transverse MRI slices for brain regions with high and low D1R density. Results The DVR varied from 2.5 ± 0.3 to 2.9 ± 0.5 in regions with high D1R density (e.g. the head of the caudate) and from 1.2 ± 0.1 to 1.6 ± 0.2 in regions with low D1R density (e.g. the prefrontal cortex). The absolute variability of the DVR ranged from 2.4% ± 1.3% to 5.1% ± 5.3%, while Bland-Altman analyses revealed very low differences in mean DVR (e.g. 0.013 ± 0.17 for the nucleus accumbens). Intraclass correlation (one-way, random) indicated very high agreement (0.93 in average) for both DVR and BPND values. Accordingly, the absolute variability of BPND ranged from 7.0% ± 4.7% to 12.5% ± 10.6%; however, there were regions with very low D1R content, such as the occipital cortex, with higher mean variability. Conclusion The test–retest reliability of D1R measurements in this study was very high. This was the case not only for D1R-rich brain areas, but also for regions with low D1R density. These results will provide a solid base for future joint PET/MRI data analyses in stimulation-dependent mapping of D1R-containing neurons and their effects on projections in neuronal circuits that determine behavior.

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Language(s): eng - English
 Dates: 2017-022017-02-142017-06
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00259-017-3645-0
PMID: 28197685
Other: Epub 2017
 Degree: -

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Title: European Journal of Nuclear Medicine and Molecular Imaging
  Other : Eur. J. Nucl. Med. Mol. Imaging
Source Genre: Journal
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Affiliations:
Publ. Info: Heidelberg, Germany : Springer-Verlag
Pages: - Volume / Issue: 44 (6) Sequence Number: - Start / End Page: 1025 - 1032 Identifier: ISSN: 1619-7070
CoNE: https://pure.mpg.de/cone/journals/resource/954925519624