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  Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder

Baczkowski, B., van Zutphen, L., Siep, N., Jacob, G. A., Domes, G., Maier, S., et al. (2017). Deficient amygdala–prefrontal intrinsic connectivity after effortful emotion regulation in borderline personality disorder. European Archives of Psychiatry and Clinical Neuroscience, 267(6), 551-565. doi:10.1007/s00406-016-0760-z.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-606C-7 Version Permalink: http://hdl.handle.net/21.11116/0000-0003-C50F-F
Genre: Journal Article

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 Creators:
Baczkowski, Blazej1, 2, Author              
van Zutphen, Linda1, Author
Siep, Nicolette1, Author
Jacob, Gitta A.3, Author
Domes, Gregor4, 5, 6, Author
Maier, Simon5, 7, Author
Sprenger, Andreas8, Author
Senft, Alena9, Author
Willenborg, Bastian9, Author
Tüscher, Oliver3, 10, Author
Arntz, Arnoud1, 11, Author
van de Ven, Vincent12, Author
Affiliations:
1Faculty of Psychology and Neuroscience, Maastricht University, the Netherlands, ou_persistent22              
2Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
3Department of Clinical Psychology and Psychotherapy, Albert Ludwigs University Freiburg, Germany, ou_persistent22              
4Department of Psychology, Albert Ludwigs University Freiburg, Germany, ou_persistent22              
5Freiburg Brain Imaging, University Medical Center, Freiburg, Germany, ou_persistent22              
6Department of Biological and Personality Psychology, University of Trier, Germany, ou_persistent22              
7Department of Psychiatry and Psychotherapy, University Medical Center, Freiburg, Germany, ou_persistent22              
8Department of Psychology, University of Lübeck, Germany, ou_persistent22              
9Department of Psychiatry and Psychotherapy, University of Lübeck, Germany, ou_persistent22              
10University of Lübeck, Germany, University Medical Center Mainz, Germany, ou_persistent22              
11Department of Psychology, University of Amsterdam, the Netherlands, ou_persistent22              
12Department of Cognitive Neuroscience, Maastricht University, the Netherlands, ou_persistent22              

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Free keywords: BPD; Emotion regulation; Amygdala; Functional connectivity; Resting-state fMRI
 Abstract: Emotion instability in borderline personality disorder (BPD) has been associated with an impaired fronto-limbic inhibitory network. However, functional connectivity (FC) underlying altered emotion regulation in BPD has yet to be established. Here, we used resting-state fMRI to investigate enduring effects of effortful emotion regulation on the amygdala intrinsic FC in BPD. In this multicenter study, resting-state fMRI was acquired before and after an emotion regulation task in 48 BPD patients and 39 non-patient comparison individuals. The bilateral amygdalae were used as a seed in the whole-brain FC analysis and two-way mixed ANOVA to test whether BPD patients exhibited weaker post-task increase in the amygdala intrinsic FC with the prefrontal cortex (PFC), compared to non-patients. Subsequently, we explored whether the results are common for personality disorders characterized by emotional problems, using additional data of 21 cluster-C personality disorder patients. In contrast to non-patients, BPD patients failed to show increased post-task amygdala resting-state FC with the medial, dorsolateral, ventrolateral PFC, and superior temporal gyrus, but surprisingly exhibited decreased FC with the posterior cingulate cortex and increased FC with the superior parietal lobule. In BPD patients, the emotion regulation task failed to increase resting-state amygdala FC with brain regions essential for effortful emotion regulation, which suggests: (a) altered cognitive control typically used to indirectly alleviate distress by reinterpreting the meaning of emotional stimuli; (b) impaired direct regulation of emotional responses, which might be common for personality disorders; (c) avoidance of self-related appraisals induced by social emotional stimuli.

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Language(s): eng - English
 Dates: 2016-06-162016-12-132016-12-302017-09
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1007/s00406-016-0760-z
PMID: 28039553
PMC: PMC5561271
Other: Epub 2016
 Degree: -

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Project name : -
Grant ID : 464-10-080
Funding program : -
Funding organization : Netherlands Organisation for Scientific Research (NWO)
Project name : -
Grant ID : JA 1785/3-1
Funding program : -
Funding organization : German Research Foundation (DFG)

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Title: European Archives of Psychiatry and Clinical Neuroscience
Source Genre: Journal
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Publ. Info: Berlin : Springer International
Pages: - Volume / Issue: 267 (6) Sequence Number: - Start / End Page: 551 - 565 Identifier: ISSN: 0940-1334
CoNE: /journals/resource/954927622119