English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  NET: A new framework for the vectorization and examination of network data

Lasser, J., & Katifori, E. (2017). NET: A new framework for the vectorization and examination of network data. Source Code for Biology and Medicine, 12: 4. doi:10.1186/s13029-017-0064-3.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-7ECC-D Version Permalink: http://hdl.handle.net/21.11116/0000-0001-1E8A-3
Genre: Journal Article

Files

show Files

Locators

show

Creators

show
hide
 Creators:
Lasser, Jana1, Author              
Katifori, Eleni1, Author              
Affiliations:
1Max Planck Research Group Physics of Biological Organization, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063293              

Content

show
hide
Free keywords: Network extraction, Data acquisition, Software, Leaf venation, Drosophila
 Abstract: Background: The analysis of complex networks both in general and in particular as pertaining to real biological systems has been the focus of intense scientific attention in the past and present. In this paper we introduce two tools that provide fast and efficient means for the processing and quantification of biological networks like Drosophila tracheoles or leaf venation patterns: the Network Extraction Tool (NET) to extract data and the Graph-edit-GUI (GeGUI) to visualize and modify networks. Results: NET is especially designed for high-throughput semi-automated analysis of biological datasets containing digital images of networks. The framework starts with the segmentation of the image and then proceeds to vectorization using methodologies from optical character recognition. After a series of steps to clean and improve the quality of the extracted data the framework produces a graph in which the network is represented only by its nodes and neighborhood-relations. The final output contains information about the adjacency matrix of the graph, the width of the edges and the positions of the nodes in space. NET also provides tools for statistical analysis of the network properties, such as the number of nodes or total network length. Other, more complex metrics can be calculated by importing the vectorized network to specialized network analysis packages. GeGUI is designed to facilitate manual correction of non-planar networks as these may contain artifacts or spurious junctions due to branches crossing each other. It is tailored for but not limited to the processing of networks from microscopy images of Drosophila tracheoles. Conclusion: The networks extracted by NET closely approximate the network depicted in the original image. NET is fast, yields reproducible results and is able to capture the full geometry of the network, including curved branches. Additionally GeGUI allows easy handling and visualization of the networks.

Details

show
hide
Language(s): eng - English
 Dates: 2017-02-08
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1186/s13029-017-0064-3
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Source Code for Biology and Medicine
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: -
Pages: 11 Volume / Issue: 12 Sequence Number: 4 Start / End Page: - Identifier: -