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  Leukocyte-common antigen and vimentin are reliable adjuncts in the diagnosis of non-Hodgkin's lymphoma in fine needle aspirates.

Domagala, W., Lasota, J., Chosia, M., Weber, K., & Osborn, M. (1989). Leukocyte-common antigen and vimentin are reliable adjuncts in the diagnosis of non-Hodgkin's lymphoma in fine needle aspirates. Analytical and Quantitative Cytology and Histology, 11(1), 15-21.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-61C9-B Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-61CB-7
Genre: Journal Article

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 Creators:
Domagala, W., Author
Lasota, J., Author
Chosia, M., Author
Weber, K.1, Author              
Osborn, M.1, Author              
Affiliations:
1Department of Biochemistry and Cell Biology, MPI for biophysical chemistry, Max Planck Society, ou_578618              

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 Abstract: Alcohol-fixed fine needle aspirates of 82 non-Hodgkin's malignant lymphomas (NHLs) were tested for the presence of vimentin and leukocyte-common antigen (LCA) by means of monoclonal antibodies (MAbs) and indirect immunofluorescence. All NHLs stained positively for vimentin; the staining was strong in all except three cases. Of the 69 NHLs tested for LCA, 1 (a large cell T-cell lymphoma) was negative while the staining was weak in 6. Thus, vimentin and LCA MAbs are sensitive, specific and reliable complementary diagnostic adjuncts that are useful in the definitive diagnosis of NHLs in alcohol-fixed fine needle aspirates. Their presence in the aspirate confirmed a cytologic diagnosis of NHL in 47 cases, helped to diagnose NHL in 31 cases in which a cytologic differential diagnosis with small cell anaplastic carcinoma could not be made with confidence and helped to change the initial cytologic diagnosis of anaplastic carcinoma to NHL in 4 cases.

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Language(s): eng - English
 Dates: 1989-02
 Publication Status: Published in print
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Title: Analytical and Quantitative Cytology and Histology
Source Genre: Journal
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Pages: - Volume / Issue: 11 (1) Sequence Number: - Start / End Page: 15 - 21 Identifier: -