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  Template-assisted extrusion of biopolymer nanofibers under physiological conditions

Raoufi, M., Aslankoohi, N., Mollenhauer, C., Böhm, H., Spatz, J. P., & Brüggemann, D. (2016). Template-assisted extrusion of biopolymer nanofibers under physiological conditions. Integrative Biology, 8(10), 1059-1066. doi:10.1039/C6IB00045B.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-82E5-0 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002E-8985-C
Genre: Journal Article

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 Creators:
Raoufi, Mohammad1, 2, Author           
Aslankoohi, Neda1, 2, Author           
Mollenhauer, Christine1, 2, Author           
Böhm, Heike1, 2, Author           
Spatz, Joachim P.1, 2, Author           
Brüggemann, Dorothea1, Author           
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

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 Abstract: Biomedical applications ranging from tissue engineering to drug delivery systems require versatile biomaterials based on the scalable and tunable production of biopolymer nanofibers under physiological conditions. These requirements can be successfully met by a novel extrusion process through nanoporous aluminum oxide templates, which is presented in this study. With this simple method we are able to control the nanofiber diameter by chosing the size of the nanopores and the concentration of the biopolymer feed solution. Nanofiber assembly into different hierarchical fiber arrangements can be achieved with a wide variety of different proteins ranging from the intracellular proteins actin, α-actinin and myosin to the extracellular matrix components collagen, fibronectin, fibrinogen, elastin and laminin. The extrusion of nanofibers can even be applied to the polysaccharides hyaluronan, chitosan and chondroitin sulphate. Moreover, blends of different proteins or proteins and polysaccharides can be extruded into composite nanofibers. With these features our template-assisted extrusion process will lead to new avenues in the development of nanofibrous biomaterials.

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Language(s): eng - English
 Dates: 2016-03-242016-07-172016-07-182016
 Publication Status: Issued
 Pages: 8
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1039/C6IB00045B
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Title: Integrative Biology
  Abbreviation : Integr. Biol.
Source Genre: Journal
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Publ. Info: Cambridge, England : Royal Society of Chemistry
Pages: - Volume / Issue: 8 (10) Sequence Number: - Start / End Page: 1059 - 1066 Identifier: ISSN: 1757-9694
CoNE: https://pure.mpg.de/cone/journals/resource/1757-9694