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  Calcium regulates the rate of rhodopsin disactivation and the primary amplification step in visual transduction.

Wagner, R., Ryba, N., & Uhl, R. (1989). Calcium regulates the rate of rhodopsin disactivation and the primary amplification step in visual transduction. FEBS Letters, 242(2), 249-254. doi:10.1016/0014-5793(89)80479-X.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-640C-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-640F-A
Genre: Journal Article

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2395654.pdf (Publisher version), 526KB
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Wagner, R.1, Author              
Ryba, N.2, Author              
Uhl, R.1, Author              
Affiliations:
1Abteilung Neurobiologie, MPI for biophysical chemistry, Max Planck Society, ou_578620              
2Department of Spectroscopy and Photochemical Kinetics, MPI for biophysical chemistry, Max Planck Society, ou_578624              

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 Abstract: The kinetics of the light-induced activation of transducin as well as the subsequent disactivation process can be monitored by means of a specific light scattering transient PA. In this communication it is demonstrated that the rate of transducin disactivation is calcium dependent, increasing when the calcium concentration is decreased. As a consequence of the accelerated recovery in low calcium, the time to the peak of the transducin activation process is shortened and the gain of the primary amplification step, i.e. the number of transducin molecules activated per bleached rhodopsin, is reduced. Experiments using hydroxylamine as an artificial quencher of rhodopsin activity suggest that calcium acts upon rhodopsin kinase and not upon the rate of the GTPase. This would indicate that calcium may control visual adaptation not only by regulating guanine cyclase activity, but also by affecting the primary step in the transduction cascade, the rhodopsin-transducin coupling

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Language(s): eng - English
 Dates: 1989-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1016/0014-5793(89)80479-X
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Title: FEBS Letters
Source Genre: Journal
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Pages: - Volume / Issue: 242 (2) Sequence Number: - Start / End Page: 249 - 254 Identifier: -