ausblenden:
Schlagwörter:
DROSOPHILA-MELANOGASTER; FRUIT-FLIES; REWARD; RATSLife Sciences & Biomedicine - Other Topics; Environmental Sciences &
Ecology; Evolutionary Biology; associative memory; Drosophila melanogaster; natural genetic variation;
opponent processes; punishment; relief;
Zusammenfassung:
A painful event establishes two opponent memories: cues that are associated with pain onset are remembered negatively, whereas cues that coincide with the relief at pain offset acquire positive valence. Such punishment-versus relief-memories are conserved across species, including humans, and the balance between them is critical for adaptive behaviour with respect to pain and trauma. In the fruit fly, Drosophila melanogaster as a study case, we found that both punishment-and relief-memories display natural variation across wild-derived inbred strains, but they do not covary, suggesting a considerable level of dissociation in their genetic effectors. This provokes the question whether there may be heritable inter-individual differences in the balance between these opponent memories in man, with potential psycho-clinical implications.
