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  Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides

Hanske, J., Wawrzinek, R., Geissner, A., Wamhoff, E.-C., Sellrie, K., Schmidt, H., et al. (2017). Calcium-independent activation of an allosteric network in Langerin by heparin oligosaccharides. ChemBioChem: A European Journal of Chemical Biology, 18(13), 1183-1187. doi:10.1002/cbic.201700027.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-7EED-3 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-C2D0-9
Genre: Journal Article

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 Creators:
Hanske, Jonas1, Author              
Wawrzinek, Robert1, Author              
Geissner, Andreas2, Author              
Wamhoff, Eike-Christian1, Author              
Sellrie, Katrin3, Author              
Schmidt, Henrik1, Author              
Seeberger, Peter H.4, Author              
Rademacher, Christoph1, Author              
Affiliations:
1Christoph Rademacher, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863300              
2Chakkumal Anish, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863299              
3Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_1863286              
4Peter H. Seeberger, Biomolekulare Systeme, Max Planck Institute of Colloids and Interfaces, Max Planck Society, ou_2040285              

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Free keywords: Immunology, Structural Biology, NMR spectroscopy, Glycobiology
 Abstract: The C-type lectin receptor Langerin is a glycan binding protein that serves as an uptake receptor on Langerhans cells and is essential for the formation of Birbeck granules. Whereas most of Langerin´s ligands are recognized via a canonical Ca2+-dependent binding site, interactions with heparins have been proposed to make additional contacts to a secondary, Ca2+-independent site. Glycan array screening and biomolecular NMR spectroscopy were employed to investigate the molecular mechanism of these interactions. We observed that binding of heparin hexasaccharides to a secondary site does not require the presence of Ca2+ and activates a previously identified intradomain allosteric network of Langerin

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 Dates: 2017-02-142017-07-04
 Publication Status: Published in print
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 Identifiers: DOI: 10.1002/cbic.201700027
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Title: ChemBioChem: A European Journal of Chemical Biology
  Other : ChemBioChem
Source Genre: Journal
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Publ. Info: Weinheim, Germany : Wiley-VCH
Pages: - Volume / Issue: 18 (13) Sequence Number: - Start / End Page: 1183 - 1187 Identifier: ISSN: 1439-4227