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  A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex

Huntenburg, J. M., Bazin, P.-L., Goulas, A., Tardif, C., Villringer, A., & Margulies, D. S. (2017). A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex. Cerebral Cortex, 27(2), 981-997. doi:10.1093/cercor/bhx030.

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Huntenburg_Bazin_2017.pdf (Verlagsversion), 2MB
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 Urheber:
Huntenburg, Julia M.1, 2, Autor           
Bazin, Pierre-Louis3, 4, Autor           
Goulas, Alexandros5, Autor           
Tardif, Christine3, 6, Autor           
Villringer, Arno3, Autor           
Margulies, Daniel S.1, Autor           
Affiliations:
1Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
2Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
6Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              

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Schlagwörter: Cortical microstructure; Functional connectivity; High-resolution MRI; Myelin imaging
 Zusammenfassung: Research in the macaque monkey suggests that cortical areas with similar microstructure are more likely to be connected. Here, we examine this link in the human cerebral cortex using 2 magnetic resonance imaging (MRI) measures: quantitative T1 maps, which are sensitive to intracortical myelin content and provide an in vivo proxy for cortical microstructure, and resting-state functional connectivity. Using ultrahigh-resolution MRI at 7 T and dedicated image processing tools, we demonstrate a systematic relationship between T1-based intracortical myelin content and functional connectivity. This effect is independent of the proximity of areas. We employ nonlinear dimensionality reduction to characterize connectivity components and identify specific aspects of functional connectivity that are linked to myelin content. Our results reveal a consistent spatial pattern throughout different analytic approaches. While functional connectivity and myelin content are closely linked in unimodal areas, the correspondence is lower in transmodal areas, especially in posteromedial cortex and the angular gyrus. Our findings are in agreement with comprehensive reports linking histologically assessed microstructure and connectivity in different mammalian species and extend them to the human cerebral cortex in vivo.

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Sprache(n): eng - English
 Datum: 2017-01-192016-09-092017-01-202017-02-102017-02-01
 Publikationsstatus: Erschienen
 Seiten: -
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Identifikatoren: DOI: 10.1093/cercor/bhx030
PMID: 28184415
PMC: PMC5390400
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Grant ID : 1U54MH091657 ; 1R01EB020740-01A1 ; 1P41EB019936-01A1 ; 3R01MH092380-04S2 ; 1U01MH108168-01
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Förderorganisation : National Institutes of Health (NIH)
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Förderorganisation : McDonnell Center for Systems Neuroscience at Washington University
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Förderprogramm : Humboldt Research Fellowship
Förderorganisation : Alexander von Humboldt Foundation

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Titel: Cerebral Cortex
Genre der Quelle: Zeitschrift
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Ort, Verlag, Ausgabe: New York, NY : Oxford University Press
Seiten: - Band / Heft: 27 (2) Artikelnummer: - Start- / Endseite: 981 - 997 Identifikator: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440