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  A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex

Huntenburg, J. M., Bazin, P.-L., Goulas, A., Tardif, C., Villringer, A., & Margulies, D. S. (2017). A systematic relationship between functional connectivity and intracortical myelin in the human cerebral cortex. Cerebral Cortex, 27(2), 981-997. doi:10.1093/cercor/bhx030.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-886F-C Version Permalink: http://hdl.handle.net/21.11116/0000-0005-4D3C-3
Genre: Journal Article

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 Creators:
Huntenburg, Julia M.1, 2, Author              
Bazin, Pierre-Louis3, 4, Author              
Goulas, Alexandros5, Author              
Tardif, Christine3, 6, Author              
Villringer, Arno3, Author              
Margulies, Daniel S.1, Author              
Affiliations:
1Max Planck Research Group Neuroanatomy and Connectivity, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_1356546              
2Department of Education and Psychology, FU Berlin, Germany, ou_persistent22              
3Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_634549              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, Leipzig, DE, ou_2205649              
5Department of Computational Neuroscience, University Medical Center Hamburg-Eppendorf, Germany, ou_persistent22              
6Cerebral Imaging Center, Douglas Mental Health University Institute, McGill University, Montréal, QC, Canada, ou_persistent22              

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Free keywords: Cortical microstructure; Functional connectivity; High-resolution MRI; Myelin imaging
 Abstract: Research in the macaque monkey suggests that cortical areas with similar microstructure are more likely to be connected. Here, we examine this link in the human cerebral cortex using 2 magnetic resonance imaging (MRI) measures: quantitative T1 maps, which are sensitive to intracortical myelin content and provide an in vivo proxy for cortical microstructure, and resting-state functional connectivity. Using ultrahigh-resolution MRI at 7 T and dedicated image processing tools, we demonstrate a systematic relationship between T1-based intracortical myelin content and functional connectivity. This effect is independent of the proximity of areas. We employ nonlinear dimensionality reduction to characterize connectivity components and identify specific aspects of functional connectivity that are linked to myelin content. Our results reveal a consistent spatial pattern throughout different analytic approaches. While functional connectivity and myelin content are closely linked in unimodal areas, the correspondence is lower in transmodal areas, especially in posteromedial cortex and the angular gyrus. Our findings are in agreement with comprehensive reports linking histologically assessed microstructure and connectivity in different mammalian species and extend them to the human cerebral cortex in vivo.

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Language(s): eng - English
 Dates: 2017-01-192016-09-092017-01-202017-02-102017-02-01
 Publication Status: Published in print
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1093/cercor/bhx030
PMID: 28184415
PMC: PMC5390400
 Degree: -

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Project name : -
Grant ID : 1U54MH091657 ; 1R01EB020740-01A1 ; 1P41EB019936-01A1 ; 3R01MH092380-04S2 ; 1U01MH108168-01
Funding program : -
Funding organization : National Institutes of Health (NIH)
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Funding program : -
Funding organization : McDonnell Center for Systems Neuroscience at Washington University
Project name : -
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Funding program : Humboldt Research Fellowship
Funding organization : Alexander von Humboldt Foundation

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Title: Cerebral Cortex
Source Genre: Journal
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Publ. Info: New York, NY : Oxford University Press
Pages: - Volume / Issue: 27 (2) Sequence Number: - Start / End Page: 981 - 997 Identifier: ISSN: 1047-3211
CoNE: https://pure.mpg.de/cone/journals/resource/954925592440