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  Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo.

Frahm, J., Bruhn, H., Gyngell, M., Merboldt, K. D., Hänicke, W., & Sauter, R. (1989). Localized high-resolution proton NMR spectroscopy using stimulated echoes: Initial applications to human brain in vivo. Magnetic Resonance in Medicine, 9(1), 79-93. doi:10.1002/mrm.1910090110.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-8B9A-7 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-0F66-5
Genre: Journal Article

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2403343.pdf (Publisher version), 852KB
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Frahm, J.1, Author              
Bruhn, H.1, Author              
Gyngell, M.1, Author              
Merboldt, K. D.1, Author              
Hänicke, W.1, Author              
Sauter, R., Author
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1Research Group of Biomedical NMR, MPI for Biophysical Chemistry, Max Planck Society, ou_578633              

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 Abstract: Water-suppressed localized proton NMR spectroscopy using stimulated echoes has been successfully applied to detect metabolites in the human brain in vivo. The STEAM spectroscopy sequence allows single-step localization by exciting three intersecting slices. Water suppression is achieved by preceding chemical-shift-selective (CHESS) rf pulses. High-resolution (0.05 ppm) proton NMR spectra of healthy volunteers have been High-resolution (0.05 ppm) proton NMR spectra of healthy volunteers have been obtained on a conventional 1.5-T whole-body MRI system (Siemens Magnetom). Volumes-of-interest (VOI) of 64 ml (4 x 4 x 4 cm3) were localized in the occipital area of the brain and spectra were recorded within measuring times ranging from 1 s (single scan) to about 10 min. The experimental procedure is described in detail. Resonance assignments include acetate, N-acetyl aspartate, gamma-amino butyrate, glutamine, glutamate, aspartate, creatine and phosphocreatine, choline-containing compounds, taurine, and inositols. Cerebral lactate was found to be at a maximum concentration of 0.5 mM when assuming N-acetyl aspartate in white matter to be 6 mM.

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Language(s): eng - English
 Dates: 1989-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.1910090110
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 79 - 93 Identifier: -