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  Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy.

Bruhn, H., Frahm, J., Frahm, J., Gyngell, M., Merboldt, K. D., Hänicke, W., et al. (1989). Cerebral metabolism in man after acute stroke: new observations using localized proton NMR spectroscopy. Magnetic Resonance in Medicine, 9(1), 126-131. doi:10.1002/mrm.1910090115.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-8C28-0 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-0F4F-C
Genre: Journal Article

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2403422.pdf (Publisher version), 328KB
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 Creators:
Bruhn, H.1, Author              
Frahm, J.1, Author              
Frahm, J.1, Author              
Gyngell, M.1, Author              
Merboldt, K. D.1, Author              
Hänicke, W.1, Author              
Sauter, R., Author
Affiliations:
1Research Group of Biomedical NMR, MPI for Biophysical Chemistry, Max Planck Society, ou_578633              

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 Abstract: Localized proton NMR spectroscopy at 1.5 T using stimulated echoes has been applied to study metabolic alterations in the postischemic phase of patients with acute cerebral infarction. A complete depletion of N-acetyl aspartate in the area of infarction has been observed in a patient studied 4 days after stroke. This finding was paralleled by a dramatic increase in the concentration of lactic acid to about 16 mM within the lesion, indicating continued anaerobic glycolysis. The diluting effect of the edema has been estimated to reduce average metabolite concentrations by about a factor of 3.

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Language(s): eng - English
 Dates: 1989-01
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/mrm.1910090115
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Title: Magnetic Resonance in Medicine
Source Genre: Journal
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Pages: - Volume / Issue: 9 (1) Sequence Number: - Start / End Page: 126 - 131 Identifier: -