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  Model-based reconstruction for T1 mapping using single-shot inversion-recovery radial FLASH.

Roeloffs, V. B., Wang, X., Sumpf, T., Untenberger, M., Voit, D., & Frahm, J. (2016). Model-based reconstruction for T1 mapping using single-shot inversion-recovery radial FLASH. International Journal of Imaging Systems and Technology, 26(4), 254-263. doi:10.1002/ima.22196.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-8E8E-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002D-16D5-9
Genre: Journal Article

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2403779.pdf (Publisher version), 702KB
 
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 Creators:
Roeloffs, V. B.1, Author              
Wang, X.1, Author              
Sumpf, T.1, Author              
Untenberger, M.1, Author              
Voit, D.1, Author              
Frahm, J.1, Author              
Affiliations:
1Biomedical NMR Research GmbH, MPI for Biophysical Chemistry, Max Planck Society, ou_578634              

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Free keywords: T1 mapping; Model-based reconstruction; Radial FLASH; Iterative reconstruction; Relaxometry
 Abstract: Quantitative parameter mapping in MRI is typically performed as a two-step procedure where serial imaging is followed by pixelwise model fitting. In contrast, model-based reconstructions directly reconstruct parameter maps from raw data without explicit image reconstruction. Here, we propose a method that determines T1 maps directly from multi-channel raw data as obtained by a single-shot inversion-recovery radial FLASH acquisition with a Golden Angle view order. Joint reconstruction of a T1, spin-density and flip-angle map is formulated as a nonlinear inverse problem and solved by the iteratively regularized Gauss-Newton method. Coil sensitivity profiles are determined from the same data in a preparatory step of the reconstruction. Validations included numerical simulations, in vitro MRI studies of an experimental T1 phantom, and in vivo studies of brain and abdomen of healthy subjects at a field strength of 3 T. The results obtained for a numerical and experimental phantom demonstrated excellent accuracy and precision of model-based T1 mapping. In vivo studies allowed for high-resolution T1 mapping of human brain (0.5–0.75 mm in-plane, 4 mm section thickness) and liver (1.0 mm, 5 mm section) within 3.6–5 s. In conclusion, the proposed method for model-based T1 mapping may become an alternative to two-step techniques, which rely on model fitting after serial image reconstruction. More extensive clinical trials now require accelerated computation and online implementation of the algorithm.

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Language(s): eng - English
 Dates: 2016-12-272016-12
 Publication Status: Published in print
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 Rev. Method: Peer
 Identifiers: DOI: 10.1002/ima.22196
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Title: International Journal of Imaging Systems and Technology
Source Genre: Journal
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Pages: - Volume / Issue: 26 (4) Sequence Number: - Start / End Page: 254 - 263 Identifier: -