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  Ion mobility-mass spectrometry and orthogonal gas-phase techniques to study amyloid formation and inhibition

Hoffmann, W., Helden, G. v., & Pagel, K. (2017). Ion mobility-mass spectrometry and orthogonal gas-phase techniques to study amyloid formation and inhibition. Current Opinion in Structural Biology, 46, 7-15. doi:10.1016/j.sbi.2017.03.002.

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Hoffmann, Waldemar1, 2, Author           
Helden, Gert von1, Author           
Pagel, Kevin1, 2, Author           
Affiliations:
1Molecular Physics, Fritz Haber Institute, Max Planck Society, ou_634545              
2Institute of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, Berlin 14195, Germany, ou_persistent22              

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 Abstract: Amyloidogenic peptide oligomers are responsible for a variety of neurodegenerative disorders such as Alzheimer’s and Parkinson’s disease. Due to their dynamic, polydisperse, and polymorphic nature, these oligomers are very challenging to characterize using traditional condensed-phase methods. In the last decade, ion mobility – mass spectrometry (IM-MS) and related gas-phase techniques have emerged as a powerful alternative to disentangle the structure and assembly characteristics of amyloid forming systems. This review highlights recent advances in which IM-MS was used to characterize amyloid oligomers and their underlying assembly pathway. In addition, we summarize recent studies in which IM-MS was used to size- and mass-select species for a further spectroscopic investigation and outline the potential of IM-MS as a tool for the screening of amyloid inhibitors.

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Language(s): eng - English
 Dates: 2017-03-062017-03-232017-10
 Publication Status: Published in print
 Pages: 9
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 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.1016/j.sbi.2017.03.002
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Title: Current Opinion in Structural Biology
  Other : Curr. Opin. Struct. Biol.
Source Genre: Journal
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Publ. Info: Amsterdam : Elsevier
Pages: - Volume / Issue: 46 Sequence Number: - Start / End Page: 7 - 15 Identifier: ISSN: 0959-440X
CoNE: https://pure.mpg.de/cone/journals/resource/954925578067