English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology

Robles, M. S., Humphrey, S. J., & Mann, M. (2017). Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metabolism, 25(1), 118-127. doi:10.1016/j.cmet.2016.10.004.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-9F6C-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-9F6D-3
Genre: Journal Article

Files

show Files

Locators

show
hide
Description:
-

Creators

show
hide
 Creators:
Robles, Maria S.1, Author              
Humphrey, Sean J.1, Author              
Mann, Matthias1, Author              
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

Content

show
hide
Free keywords: GENE-EXPRESSION; CELL BIOLOGY; CLOCK; REVEALS; LIVER; PROTEOMICS; AUTOPHAGY; MAMMALS; ALPHA; MOUSECell Biology; Endocrinology & Metabolism;
 Abstract: Circadian clocks are self-sustainable endogenous oscillators, present in virtually every cell, driving daily cycles of metabolism and physiology. The molecular mechanism of the circadian clock is based on interconnected transcriptional and translational feedback loops. While many studies have addressed circadian rhythms of the transcriptome and, to a lesser extent, the proteome, none have investigated the phosphoproteome. We apply mass spectrometry-based phosphoproteomics to obtain the first global in vivo quantification of circadian phosphorylation in mammals. Of more than 20,000 phosphosites, 25% significantly oscillate in the mouse liver, including novel sites on core clock proteins. The extent and amplitude of phosphorylation cycles far exceeds those observed in RNA and protein abundance. Our data indicate a dominant regulatory role for phosphorylation- dependent circadian tuning of signaling pathways. This allows the organism to integrate different signals and rapidly and economically respond to daily changes in nutrient availability and physiological states.

Details

show
hide
Language(s): eng - English
 Dates: 2016-11-032017-01-10
 Publication Status: Published in print
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Method: -
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Cell Metabolism
  Other : Cell Metabolism
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 25 (1) Sequence Number: - Start / End Page: 118 - 127 Identifier: ISSN: 1550-4131
CoNE: /journals/resource/111088195284928