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  Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology

Robles, M. S., Humphrey, S. J., & Mann, M. (2017). Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology. Cell Metabolism, 25(1), 118-127. doi:10.1016/j.cmet.2016.10.004.

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 Creators:
Robles, Maria S.1, Author           
Humphrey, Sean J.1, Author           
Mann, Matthias1, Author           
Affiliations:
1Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: GENE-EXPRESSION; CELL BIOLOGY; CLOCK; REVEALS; LIVER; PROTEOMICS; AUTOPHAGY; MAMMALS; ALPHA; MOUSECell Biology; Endocrinology & Metabolism;
 Abstract: Circadian clocks are self-sustainable endogenous oscillators, present in virtually every cell, driving daily cycles of metabolism and physiology. The molecular mechanism of the circadian clock is based on interconnected transcriptional and translational feedback loops. While many studies have addressed circadian rhythms of the transcriptome and, to a lesser extent, the proteome, none have investigated the phosphoproteome. We apply mass spectrometry-based phosphoproteomics to obtain the first global in vivo quantification of circadian phosphorylation in mammals. Of more than 20,000 phosphosites, 25% significantly oscillate in the mouse liver, including novel sites on core clock proteins. The extent and amplitude of phosphorylation cycles far exceeds those observed in RNA and protein abundance. Our data indicate a dominant regulatory role for phosphorylation- dependent circadian tuning of signaling pathways. This allows the organism to integrate different signals and rapidly and economically respond to daily changes in nutrient availability and physiological states.

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Language(s): eng - English
 Dates: 2016-11-032017-01-10
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
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Title: Cell Metabolism
  Other : Cell Metabolism
Source Genre: Journal
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Publ. Info: Cambridge, MA : Cell Press
Pages: - Volume / Issue: 25 (1) Sequence Number: - Start / End Page: 118 - 127 Identifier: ISSN: 1550-4131
CoNE: https://pure.mpg.de/cone/journals/resource/111088195284928