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  Casein Kinase 1 Coordinates Cohesin Cleavage, Gametogenesis, and Exit from M Phase in Meiosis II

Argüello-Miranda, O., Zagoriy, I., Mengoli, V., Rojas, J., Jonak, K., Oz, T., et al. (2017). Casein Kinase 1 Coordinates Cohesin Cleavage, Gametogenesis, and Exit from M Phase in Meiosis II. Developmental Cell, 40(1), 37-52. doi:10.1016/j.devcel.2016.11.021.

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 Creators:
Argüello-Miranda, Orlando1, Author              
Zagoriy, Ievgeniia1, Author              
Mengoli, Valentina1, Author              
Rojas, Julie1, Author              
Jonak, Katarzyna1, Author              
Oz, Tugce1, Author              
Graf, Peter1, Author              
Zachariae, Wolfgang1, Author              
Affiliations:
1Zachariae, Wolfgang / Chromosome Biology, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565176              

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Free keywords: SPINDLE POLE BODY; CHROMOSOME SEGREGATION; BUDDING YEAST; SACCHAROMYCES-CEREVISIAE; HOMOLOGOUS CHROMOSOMES; CENTROMERIC COHESION; PROSPORE MEMBRANE; SHUGOSHIN; ANAPHASE; PHOSPHORYLATIONCell Biology; Developmental Biology;
 Abstract: Meiosis consists of DNA replication followed by two consecutive nuclear divisions and gametogenesis or spore formation. While meiosis I has been studied extensively, less is known about the regulation of meiosis II. Here we show that Hrr25, the conserved casein kinase 18 of budding yeast, links three mutually independent key processes of meiosis II. First, Hrr25 induces nuclear division by priming centromeric cohesin for cleavage by separase. Hrr25 simultaneously phosphorylates Rec8, the cleavable subunit of cohesin, and removes from centromeres the cohesin protector composed of shugoshin and the phosphatase PP2A. Second, Hrr25 initiates the sporulation program by inducing the synthesis of membranes that engulf the emerging nuclei at anaphase II. Third, Hrr25 mediates exit from meiosis II by activating pathways that trigger the destruction of M-phase-promoting kinases. Thus, Hrr25 synchronizes formation of the single-copy genome with gamete differentiation and termination of meiosis.

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Language(s): eng - English
 Dates: 2016-12-222017
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Degree: -

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Title: Developmental Cell
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 40 (1) Sequence Number: - Start / End Page: 37 - 52 Identifier: ISSN: 1534-5807
CoNE: https://pure.mpg.de/cone/journals/resource/111006902714134