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  Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism

Kory, N., Grond, S., Kamat, S. S., Li, Z., Krahmer, N., Chitraju, C., et al. (2017). Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism. Journal of Lipid Research, 58(1), 226-235. doi:10.1194/jlr.M072538.

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http://www.jlr.org/content/58/1/226 (Publisher version)
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 Creators:
Kory, Nora1, Author
Grond, Susanne1, Author
Kamat, Siddhesh S.1, Author
Li, Zhihuan1, Author
Krahmer, Natalie2, Author           
Chitraju, Chandramohan1, Author
Zhou, Ping1, Author
Frohlich, Florian1, Author
Semova, Ivana1, Author
Ejsing, Christer1, Author
Zechner, Rudolf1, Author
Cravatt, Benjamin F.1, Author
Farese Jr., Robert V.1, Author
Walther, Tobias C.1, Author
Affiliations:
1external, ou_persistent22              
2Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society, ou_1565159              

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Free keywords: HORMONE-SENSITIVE LIPASE; COHORT CONSORTIUM; HIGH CONFIDENCE; RISK VARIANTS; PROTEINS; MACROPHAGES; HYDROLYSIS; EXPRESSION; BREAST; ACCUMULATIONBiochemistry & Molecular Biology; lipase; lipoprotein metabolism; cholesterol efflux; triglycerides; animal models;
 Abstract: Variations in the gene LDAH (C2ORF43), which encodes lipid droplet-associated hydrolase (LDAH), are among few loci associated with human prostate cancer. Homologs of LDAH have been identified as proteins of lipid droplets (LDs). LDs are cellular organelles that store neutral lipids, such as triacylglycerols and sterol esters, as precursors for membrane components and as reservoirs of metabolic energy. LDAH is reported to hydrolyze cholesterol esters and to be important in macrophage cholesterol ester metabolism. Here, we confirm that LDAH is localized to LDs in several model systems. We generated a murine model in which Ldah is disrupted but found no evidence for a major function of LDAH in cholesterol ester or triacylglycerol metabolism in vivo, nor a role in energy or glucose metabolism.(Jlr) Our data suggest that LDAH is not a major cholesterol ester hydrolase, and an alternative metabolic function may be responsible for its possible effect on development of prostate cancer.

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Language(s): eng - English
 Dates: 2016-11-112017-01
 Publication Status: Issued
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: ISI: 000392408700019
DOI: 10.1194/jlr.M072538
 Degree: -

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Title: Journal of Lipid Research
Source Genre: Journal
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Publ. Info: Bethesda, Md. : American Society for Biochemistry and Molecular Biology
Pages: - Volume / Issue: 58 (1) Sequence Number: - Start / End Page: 226 - 235 Identifier: ISSN: 0022-2275
CoNE: https://pure.mpg.de/cone/journals/resource/954925414928