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  Fast propagation regions cause self-sustained reentry in excitable media

Zykov, V. S., Krekhov, A., & Bodenschatz, E. (2017). Fast propagation regions cause self-sustained reentry in excitable media. Proceedings of the National Academy of Sciences of the United States of America, 114(6), 1281-1286. doi:10.1073/pnas.1611475114.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A3E0-B Version Permalink: http://hdl.handle.net/21.11116/0000-0001-7A71-7
Genre: Journal Article

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 Creators:
Zykov, Vladimir S.1, Author              
Krekhov, Alexei1, Author              
Bodenschatz, Eberhard1, Author              
Affiliations:
1Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society, ou_2063287              

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Free keywords: excitable media; spirals; reentry; cardiology; ablation
 Abstract: Self-sustained waves of electrophysiological activity can cause arrhythmia in the heart. These reentrant excitations have been associated with spiral waves circulating around either an anatomically defined weakly conducting region or a functionally determined core. Recently, an ablation procedure has been clinically introduced that stops atrial fibrillation of the heart by destroying the electrical activity at the spiral core. This is puzzling because the tissue at the anatomically defined spiral core would already be weakly conducting, and a further decrease should not improve the situation. In the case of a functionally determined core, an ablation procedure should even further stabilize the rotating wave. The efficacy of the procedure thus needs explanation. Here, we show theoretically that fundamentally in any excitable medium a region with a propagation velocity faster than its surrounding can act as a nucleation center for reentry and can anchor an induced spiral wave. Our findings demonstrate a mechanistic underpinning for the recently developed ablation procedure. Our theoretical results are based on a very general and widely used two-component model of an excitable medium. Moreover, the important control parameters used to realize conditions for the discovered phenomena are applicable to quite different multicomponent models.

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Language(s): eng - English
 Dates: 2017-01-25
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Identifiers: DOI: 10.1073/pnas.1611475114
 Degree: -

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Title: Proceedings of the National Academy of Sciences of the United States of America
Source Genre: Journal
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Pages: - Volume / Issue: 114 (6) Sequence Number: - Start / End Page: 1281 - 1286 Identifier: -