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  Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory

Celikel, T., Marx, V., Freudenberg, F., Zivkovic, A., Resnik, E., Hasan, M. T., et al. (2007). Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory. Frontiers in Neuroscience, 1(1), 97-110. doi:10.3389/neuro.01.1.1.007.2007.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A787-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A788-8
Genre: Journal Article
Alternative Title : Select overexpression of Homer1a in dorsal hippocampus impairs spatial working memory

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FrontNeurosci_1_2007_97.pdf (Any fulltext), 726KB
 
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 Creators:
Celikel, Tansu1, Author              
Marx, Verena2, Author              
Freudenberg, Florian2, Author              
Zivkovic, Aleksandar, Author
Resnik, Evgeny2, Author              
Hasan, Mazahir T.2, 3, Author              
Licznerski, Pawel2, Author              
Osten, Pavel2, Author              
Rozov, Andrej1, 2, Author              
Seeburg, Peter H.2, Author              
Schwarz, Martin K.2, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
3Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

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Free keywords: hippocampus, viral expression, synaptic plasticity, Homer1a, immediate early gene, spatial reference memory, spatial working memory
 Abstract: Long Homer proteins forge assemblies of signaling components involved in glutamate receptor signaling in postsynaptic excitatory neurons, including those underlying synaptic transmission and plasticity. The short immediate-early gene (IEG) Homer1a can dynamically uncouple these physical associations by functional competition with long Homer isoforms. To examine the consequences of Homer1a-mediated “uncoupling” for synaptic plasticity and behavior, we generated forebrain-specific tetracycline (tet) controlled expression of Venus-tagged Homer1a (H1aV) in mice. We report that sustained overexpression of H1aV impaired spatial working but not reference memory. Most notably, a similar impairment was observed when H1aV expression was restricted to the dorsal hippocampus (HP), which identifies this structure as the principal cortical area for spatial working memory. Interestingly, H1aV overexpression also abolished maintenance of CA3-CA1 long-term potentiation (LTP). These impairments, generated by sustained high Homer1a levels, identify a requirement for long Homer forms in synaptic plasticity and temporal encoding of spatial memory.

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Language(s): eng - English
 Dates: 2007-08-152007-09-012007-10-152007-11-01
 Publication Status: Published in print
 Pages: 14
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 1 (1) Sequence Number: - Start / End Page: 97 - 110 Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548