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  Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating

Dieckmann, M., Freudenberg, F., Klein, S., Koch, M., & Schwabe, K. (2007). Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating. Schizophrenia Research, 97(1), 250-253. doi:10.1016/j.schres.2007.08.007.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-A7A4-8 Version Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-A7A5-6
Genre: Journal Article
Alternative Title : Disturbed social behavior and motivation in rats selectively bred for deficient sensorimotor gating

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SchizophrenRes_97_2007_250.pdf (Any fulltext), 119KB
 
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 Creators:
Dieckmann, Marco, Author
Freudenberg, Florian1, Author           
Klein, Steffen2, Author           
Koch, Mirja3, Author           
Schwabe, Kerstin, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
3Max Planck Research Group Behavioural Neurophysiology (Andreas T. Schaefer), Max Planck Institute for Medical Research, Max Planck Society, ou_1497722              

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Free keywords: Negative symptoms; Endophenotype; Prepulse inhibition; Schizophrenia
 Abstract: Deficient prepulse inhibition (PPI) of startle reflects disturbed sensorimotor gating found in certain neuropsychiatric disorders. We here tested whether rats selectively bred for deficient PPI are deteriorated in behavioral paradigms used to model negative symptoms of schizophrenia. Rats with low PPI preferred standard rat-chow when having the choice between lever-pressing for reward-pellets or freely available rat-chow, suggesting reduced motivation. Additionally, these rats show deteriorated social behavior during interaction with a juvenile rat. Rats selectively bred for low PPI may therefore be used as a model to study the biological mechanisms and therapeutic strategies of negative symptoms of schizophrenia.

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Language(s): eng - English
 Dates: 2007-07-312007-06-092007-08-072007-09-122007-12-01
 Publication Status: Issued
 Pages: 4
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664867
DOI: 10.1016/j.schres.2007.08.007
URI: http://www.ncbi.nlm.nih.gov/pubmed/17855056
URI: http://dx.doi.org/10.1016/j.schres.2007.08.007
URI: http://www.sciencedirect.com/science/article/pii/S0920996407003635/pdf?md5=09c3343b4bd192301d40e93b40ae6ebe&pid=1-s2.0-S0920996407003635-main.pdf
Other: 7243
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Title: Schizophrenia Research
  Abbreviation : Schizophr Res.
Source Genre: Journal
 Creator(s):
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Pages: - Volume / Issue: 97 (1) Sequence Number: - Start / End Page: 250 - 253 Identifier: ISSN: 0920-9964