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  Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex

Frick, A., Feldmeyer, D., & Sakmann, B. (2007). Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex. The Journal of Physiology - London, 585(1), 103-116. doi:10.1113/jphysiol.2007.141788.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A7F8-A Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-A7F9-8
Genre: Journal Article
Alternative Title : Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex

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Frick, Andreas1, 2, Author              
Feldmeyer, Dirk1, Author              
Sakmann, Bert1, Author              
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1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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 Abstract: The probability of synaptic transmitter release determines the spread of excitation and the possible range of computations at unitary connections. To investigate whether synaptic properties between neocortical pyramidal neurons change during the assembly period of cortical circuits, whole−cell voltage recordings were made simultaneously from two layer 5A (L5A) pyramidal neurons within the cortical columns of rat barrel cortex. We found that synaptic transmission between L5A pyramidal neurons is very reliable between 2 and 3 weeks of postnatal development with a mean unitary EPSP amplitude of ˜1.2 mV, but becomes less efficient and fails more frequently in the more mature cortex of ˜4 weeks of age with a mean unitary EPSP amplitude of 0.65 mV. Coefficient of variation and failure rate increase as the unitary EPSP amplitude decreases during development. The paired−pulse ratio (PPR) of synaptic efficacy at 10 Hz changes from 0.7 to 1.04. Despite the overall increase in PPR, short−term plasticity displays a large variability at 4 weeks, ranging from strong depression to strong facilitation (PPR, range 0.6−2.1), suggesting the potential for use−dependent modifications at this intracortical synapse. In conclusion, the transmitter release probability at the L5A−L5A connection is developmentally regulated in such a way that in juvenile animals excitation by single action potentials is efficiently transmitted, whereas in the more mature cortex synapses might be endowed with a diversity of filtering characteristics

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Title: The Journal of Physiology - London
Source Genre: Journal
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Publ. Info: London : Cambridge University Press
Pages: - Volume / Issue: 585 (1) Sequence Number: - Start / End Page: 103 - 116 Identifier: ISSN: 0022-3751
CoNE: https://pure.mpg.de/cone/journals/resource/954925334693_2