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  Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning

Johnson, A. W., Bannerman, D. M., Rawlins, J. N. P., Sprengel, R., & Good, M. A. (2007). Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning. Behavioral Neuroscience, 121(6), 1192-1202. doi:10.1037/0735-7044.121.6.1192.

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Genre: Journal Article
Alternative Title : Targeted deletion of the GluR-1 AMPA receptor in mice dissociates general and outcome-specific influences of appetitive rewards on learning

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BehavNeurosci_121_2007_1192.pdf (Any fulltext), 828KB
 
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Johnson, Alexander W., Author
Bannerman, David M., Author
Rawlins, John Nicholas P., Author
Sprengel, Rolf1, Author              
Good, Mark A., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: AMPA, receptor, motivation, mouse, amygdala
 Abstract: The authors assessed the hypothesis that deletion of the GluR-1 subtype of the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor in mice disrupts the associative activation of a sensory-specific representation of an appetitive reward. In Experiment 1, mice received training on a Pavlovian-instrumental transfer task. In the test stage, conditioned stimulus (CS) presentations enhanced instrumental actions in both groups. However, this effect was specific to the action that shared the same outcome as the CS in wild-type (WT), but not GluR-1-super(-/-), mice. In Experiment 2, the mice were trained on a heterogeneous instrumental chain in which rewards were obtained for emitting 1 response (R1, that was distal to reward delivery), followed by a 2nd response (R2, that was proximal to reward delivery). A change in general motivational state (from hungry to sated) reduced the number of R2 responses in both groups. In contrast, an outcome-specific satiety treatment produced a selective decline in R1 responding only in WT mice. The results support the hypothesis that GluR-1 deletion impairs the associative activation of a representation of the sensory-specific incentive motivational properties of an appetitive reward.

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Language(s): eng - English
 Dates: 2007-07-182007-04-272007-07-252007-12-01
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Behavioral Neuroscience
Source Genre: Journal
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Publ. Info: Baltimore, Md. : American Psychological Association (PsycARTICLES)
Pages: - Volume / Issue: 121 (6) Sequence Number: - Start / End Page: 1192 - 1202 Identifier: ISSN: 0735-7044
CoNE: https://pure.mpg.de/cone/journals/resource/954927546238