English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex

Kerr, J., de Kock, C., Greenberg, D., Bruno, R. M., Sakmann, B., & Helmchen, F. (2007). Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex. The Journal of Neuroscience, 27(48), 13316-13328. doi:10.1523/JNEUROSCI.2210-07.2007.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Spatial organization of neuronal population responses in layer 2/3 of rat barrel cortex

Files

show Files
hide Files
:
JNeurosci_27_2007_13316.pdf (Any fulltext), 7MB
 
File Permalink:
-
Name:
JNeurosci_27_2007_13316.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Description:
-

Creators

show
hide
 Creators:
Kerr, Jason1, 2, Author              
de Kock, Christiaan1, Author              
Greenberg, David1, Author              
Bruno, Randy M.1, Author              
Sakmann, Bert1, Author              
Helmchen, Fritjof1, Author              
Affiliations:
1Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              
2Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

Content

show
hide
Free keywords: population imaging; spatial organization; orientation selection; correlation; activity patterns; cortex; population coding; somatosensory; vibrissa (whisker)
 Abstract: Individual pyramidal neurons of neocortex show sparse and variable responses to sensory stimuli in vivo. It has remained unclear how this variability extends to population responses on a trial-to-trial basis. Here, we characterized single-neuron and population responses to whisker stimulation in layer 2/3 (L2/3) of identified columns in rat barrel cortex using in vivo two-photon calcium imaging. Optical detection of single action potentials from evoked calcium transients revealed low spontaneous firing rates (0.25 Hz), variable response probabilities (range, 0–0.5; mean, 0.2 inside barrel column), and weak angular tuning of L2/3 neurons. On average, both the single-neuron response probability and the percentage of the local population activated were higher in the barrel column than above septa or in neighboring columns. Within the barrel column, mean response probability was highest in the center (0.4) and declined toward the barrel border. Neuronal pairs showed correlations in both spontaneous and sensory-evoked activity that depended on the location of the neurons. Correlation decreased with increasing distance between neurons and, for neuronal pairs the same distance apart, with distance of the pair from the barrel column center. Although neurons are therefore not activated independently from each other, we did not observe precisely repeating spatial activation patterns. Instead, population responses showed large trial-to-trial variability. Nevertheless, the accuracy of decoding stimulus onset times from local population activity increased with population size and depended on anatomical location. We conclude that, despite their sparseness and variability, L2/3 population responses show a clear spatial organization on the columnar scale.

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Neuroscience
  Other : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Baltimore, MD : The Society
Pages: - Volume / Issue: 27 (48) Sequence Number: - Start / End Page: 13316 - 13328 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187