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  Functional sensitivity of 2D simultaneous multi-slice echo-planar imaging: Effects of acceleration on g-factor and physiological noise

Todd, N., Josephs, O., Zeidman, P., Flandin, G., Moeller, S., & Weiskopf, N. (2017). Functional sensitivity of 2D simultaneous multi-slice echo-planar imaging: Effects of acceleration on g-factor and physiological noise. Frontiers in Neuroscience, 11: 158. doi:10.3389/fnins.2017.00158.

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Item Permalink: https://hdl.handle.net/11858/00-001M-0000-002C-C84D-4 Version Permalink: https://hdl.handle.net/21.11116/0000-0005-4F59-0
Genre: Journal Article

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 Creators:
Todd, Nick1, 2, Author
Josephs, Oliver2, Author
Zeidman, Peter2, Author
Flandin, Guillaume2, Author
Moeller, Steen3, Author
Weiskopf, Nikolaus2, 4, Author           
Affiliations:
1Department of Radiology, Harvard Medical School, Boston, MA, USA, ou_persistent22              
2Wellcome Trust Centre for Neuroimaging, University College London, United Kingdom, ou_persistent22              
3Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, USA, ou_persistent22              
4Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society, ou_2205649              

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Free keywords: Simultaneous multi-slice; SMS; fMRI; Fast imaging; Acceleration; SNR; tSNR; High frequency noise; BOLD sensitivity
 Abstract: Accelerated data acquisition with simultaneous multi-slice (SMS) imaging for functional MRI studies leads to interacting and opposing effects that influence the sensitivity to blood oxygen level-dependent (BOLD) signal changes. Image signal to noise ratio (SNR) is decreased with higher SMS acceleration factors and shorter repetition times (TR) due to g-factor noise penalties and saturation of longitudinal magnetization. However, the lower image SNR is counteracted by greater statistical power from more samples per unit time and a higher temporal Nyquist frequency that allows for better removal of spurious non-BOLD high frequency signal content. This study investigated the dependence of the BOLD sensitivity on these main driving factors and their interaction, and provides a framework for evaluating optimal acceleration of SMS-EPI sequences. fMRI data from a scenes/objects visualization task was acquired in 10 healthy volunteers at a standard neuroscience resolution of 3mm on a 3T MRI scanner. SMS factors 1, 2, 4, and 8 were used, spanning TRs of 2800 ms to 350 ms. Two data processing methods were used to equalize the number of samples over the SMS factors. BOLD sensitivity was assessed using g-factors maps, temporal SNR (tSNR), and t-score metrics. tSNR results show a dependence on SMS factor that is highly non-uniform over the brain, with outcomes driven by g-factor noise amplification and the presence of high frequency noise. The t-score metrics also show a high degree of spatial dependence: the lower g-factor noise area of V1 shows significant improvements at higher SMS factors; the moderate-level g-factor noise area of the parahippocampal place area shows only a trend of improvement; and the high g-factor noise area of the ventral-medial pre-frontal cortex shows a trend of declining t-scores at higher SMS factors. This spatial variability suggests that the optimal SMS factor for fMRI studies is region dependent. For task fMRI studies done with similar parameters as were used here (3T scanner, 32-channel RF head coil, whole brain coverage at 3mm isotropic resolution), we recommend SMS accelerations of 4x (conservative) to 8x (aggressive) for most studies and a more conservative acceleration of 2x for studies interested in anterior midline regions.

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Language(s): eng - English
 Dates: 2016-12-072017-03-102017-03-29
 Publication Status: Published online
 Pages: -
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: DOI: 10.3389/fnins.2017.00158
PMID: 28424572
PMC: PMC5372803
Other: eCollection 2017
 Degree: -

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Project name : Non-invasive in vivo histology in health and disease using Magnetic Resonance Imaging (MRI) / HMRI
Grant ID : 616905
Funding program : FP7 (ERC-2013-CoG)
Funding organization : European Research Council (ERC)
Project name : Talking imaging into the therapeutic domain: Self-regulation of brain systems for mental disorders / BRAINTRAIN
Grant ID : 602186
Funding program : Funding Programme 7 (FP7-HEALTH-2013-INNOVATION-1)
Funding organization : European Union (EU)
Project name : Multidisciplinary Training in Image Guided Therapy
Grant ID : 5R25CA089017-13
Funding program : -
Funding organization : National Institute of Health (NIH)
Project name : -
Grant ID : -
Funding program : -
Funding organization : Wellcome Trust (WT)

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Title: Frontiers in Neuroscience
  Other : Front Neurosci
Source Genre: Journal
 Creator(s):
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 11 Sequence Number: 158 Start / End Page: - Identifier: ISSN: 1662-4548
ISSN: 1662-453X
CoNE: https://pure.mpg.de/cone/journals/resource/1662-4548