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  Structure of the transcription regulator CcpA from Lactococcus lactis

Loll, B., Kowalczyk, M., Alings, C., Chieduch, A., Bardowski, J., Saenger, W., et al. (2007). Structure of the transcription regulator CcpA from Lactococcus lactis. Acta Crystallographica. Section D: Biological Crystallography (Copenhagen), 63, 431-436. doi:10.1107/S0907444907000546.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-AB29-D Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-AB2A-B
Genre: Journal Article
Alternative Title : Structure of the transcription regulator CcpA from Lactococcus lactis

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ActaCrystD_63_2007_431.pdf (Any fulltext), 511KB
 
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 Creators:
Loll, Bernhard1, Author              
Kowalczyk, Magdalena, Author
Alings, Claudia, Author
Chieduch, André, Author
Bardowski, Jacek, Author
Saenger, Wolfram, Author
Biesiadka, Jacek, Author
Affiliations:
1Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society, ou_1497700              

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Free keywords: DNA-binding protein/regulation; MALDI-TOF mass spectrometry
 Abstract: Catabolite control protein A (CcpA) functions as master transcriptional regulator of carbon catabolism in Firmicutes. It belongs to the family of bacterial repressor/regulator proteins. Here, the crystal structure of the 76 kDa homodimeric CcpA protein from Lactococcus lactis subsp. lactis IL1403 is presented at 1.9 A resolution in the absence of cognate DNA. The phases were derived by molecular replacement and the structure was refined to crystallographic R and R(free) factors of 0.177 and 0.211, respectively. The presence of a sulfate molecule in the direct vicinity of a putative effector-binding site in the monomer allowed the derivation of a model for the possible binding of small organic effector molecules.

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Language(s): eng - English
 Dates: 2006-12-082007-01-052007-03-162007-04-01
 Publication Status: Published in print
 Pages: 6
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

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Title: Acta Crystallographica. Section D: Biological Crystallography (Copenhagen)
  Other : Acta Crystallogr D
Source Genre: Journal
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Publ. Info: [Copenhagen, Denmark : Published for the International Union of Crystallography by Munksgaard]
Pages: - Volume / Issue: 63 Sequence Number: - Start / End Page: 431 - 436 Identifier: ISSN: 0907-4449
CoNE: https://pure.mpg.de/cone/journals/resource/954925562619