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  Early functional development of interneurons in the zebrafish olfactory bulb

Mack-Bucher, J. A., Li, J., & Friedrich, R. W. (2007). Early functional development of interneurons in the zebrafish olfactory bulb. European Journal of Neuroscience: European Neuroscience Association, 25(2), 460-470. doi:10.1111/j.1460-9568.2006.05290.x.

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Genre: Journal Article
Alternative Title : Early functional development of interneurons in the zebrafish olfactory bulb

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Mack-Bucher, Julia Angela1, Author           
Li, Jun2, Author           
Friedrich, Rainer W.1, Author           
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1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: development; GABA; inhibition; interneurons; olfactory bulb
 Abstract: In the adult olfactory bulb (OB) of vertebrates, local GABAergic interneurons (INs) mediate recurrent and lateral inhibition between the principal neurons of the OB, the mitral cells (MCs), and play pivotal roles in the processing of odor-evoked activity patterns. The properties and functions of INs in the developing OB are, however, not well understood. We studied the functional development of INs in the OB of living zebrafish larvae 3–6 days postfertilization using anatomical techniques and in-vivo two-photon Ca2+ imaging. We identified MCs and INs by cell-type-specific expression of transgenic fluorescent markers and found that the IN : MC ratio was lower than in the adult fish. Moreover, the fraction of INs responding with Ca2+ signals to a set of natural odors was substantially lower than in adults. Odors of different chemical classes evoked overlapping patterns of Ca2+ signals that were concentrated in the center of the IN layer. The GABAA receptor agonists GABA and muscimol strongly suppressed odor responses, whereas a GABAA receptor antagonist enhanced responses and altered the spatial distribution of odor-evoked activity. These results indicate that IN odor responses at early developmental stages are sparse and exhibit no obvious chemotopic organization. Nevertheless, GABAergic signaling is already inhibitory at early stages of OB development and strongly influences odor-evoked activity patterns. Hence, INs already participate in the processing of odor information at very early stages of OB development even though the majority of INs emerge only at later stages.

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Language(s): eng - English
 Dates: 2006-11-082006-10-102006-11-092007-01-242007-01-01
 Publication Status: Published in print
 Pages: 11
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
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Title: European Journal of Neuroscience : European Neuroscience Association
  Other : Eur. J. Neurosci
Source Genre: Journal
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Publ. Info: Oxford, UK : Published on behalf of the European Neuroscience Association by Oxford University Press
Pages: - Volume / Issue: 25 (2) Sequence Number: - Start / End Page: 460 - 470 Identifier: ISSN: 0953-816X
CoNE: https://pure.mpg.de/cone/journals/resource/954925575988