English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning

Humeau, Y., Reisel, D., Johnson, A. W., Borchardt, T., Jensen, V., Gebhardt, C., et al. (2007). A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning. The Journal of Neuroscience, 27(41), 10947-10956. doi:10.1523/JNEUROSCI.2603-07.2007.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : A pathway-specific function for different AMPA receptor subunits in amygdala long-term potentiation and fear conditioning

Files

show Files
hide Files
:
JNeurosci_27_2007_10947.pdf (Any fulltext), 481KB
 
File Permalink:
-
Name:
JNeurosci_27_2007_10947.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Humeau, Yann, Author
Reisel, Daniel, Author
Johnson, Alexander W., Author
Borchardt, Thilo1, Author           
Jensen, Vidar, Author
Gebhardt, Christine, Author
Bosch, Verena1, Author           
Gass, Peter, Author
Bannerman, David M., Author
Good, Mark A., Author
Hvalby, Øivind, Author
Sprengel, Rolf1, Author           
Lüthi, Andreas, Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

Content

show
hide
Free keywords: lateral amygdala; basal amygdala; fear conditioning; synaptic transmission; LTP; GluR1; GluR3
 Abstract: The AMPA receptor subunit glutamate receptor 1 (GluR1 or GluR-A) contributes to amygdala-dependent emotional learning. It remains unclear, however, to what extent different amygdala pathways depend on GluR1, or other AMPA receptor subunits, for proper synaptic transmission and plasticity, and whether GluR1-dependent long-term potentiation (LTP) is necessary for auditory and contextual fear conditioning. Here, we dissected the role of GluR1 and GluR3 (GluR-C) subunits in AMPA receptor-dependent amygdala LTP and fear conditioning using knock-out mice (GluR1-/- and GluR3-/-). We found that, whereas LTP at thalamic inputs to lateral amygdala (LA) projection neurons and at glutamatergic synapses in the basal amygdala was completely absent in GluR1-/- mice, both GluR1 and GluR3 contributed to LTP in the cortico-LA pathway. Because both auditory and contextual fear conditioning were selectively impaired in GluR1-/- but not GluR3-/- mice, we conclude that GluR1-dependent synaptic plasticity is the dominant form of LTP underlying the acquisition of auditory and contextual fear conditioning, and that plasticity in distinct amygdala pathways differentially contributes to aversive conditioning.

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: The Journal of Neuroscience
  Other : The Journal of Neuroscience: the Official Journal of the Society for Neuroscience
  Abbreviation : J. Neurosci.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Washington, DC : Society of Neuroscience
Pages: - Volume / Issue: 27 (41) Sequence Number: - Start / End Page: 10947 - 10956 Identifier: ISSN: 0270-6474
CoNE: https://pure.mpg.de/cone/journals/resource/954925502187_1