Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
  Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development

Ryu, S., Mahler, J., Acampora, D., Holzschuh, J., Erhardt, S., Omodei, D., et al. (2007). Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development. Current Biology, 17(10), 873-880. doi:10.1016/j.cub.2007.04.003.

Item is

Basisdaten

einblenden: ausblenden:
Genre: Zeitschriftenartikel
Alternativer Titel : Orthopedia homeodomain protein is essential for diencephalic dopaminergic neuron development

Dateien

einblenden: Dateien
ausblenden: Dateien
:
CurrBiol_17_2007_873.pdf (beliebiger Volltext), 2MB
 
Datei-Permalink:
-
Name:
CurrBiol_17_2007_873.pdf
Beschreibung:
-
OA-Status:
Sichtbarkeit:
Eingeschränkt (Max Planck Institute for Medical Research, MHMF; )
MIME-Typ / Prüfsumme:
application/pdf
Technische Metadaten:
Copyright Datum:
-
Copyright Info:
-
Lizenz:
-

Externe Referenzen

einblenden:
ausblenden:
Beschreibung:
-
OA-Status:
externe Referenz:
http://dx.doi.org/10.1016/j.cub.2007.04.003 (beliebiger Volltext)
Beschreibung:
-
OA-Status:

Urheber

einblenden:
ausblenden:
 Urheber:
Ryu, Soojin1, Autor           
Mahler, Julia, Autor
Acampora, Dario, Autor
Holzschuh, Jochen, Autor
Erhardt, Simone, Autor
Omodei, Daniela, Autor
Simeone, Antonio, Autor
Driever, Wolfgang, Autor
Affiliations:
1Max Planck Research Group Developmental Genetics of the nervous system (Soojin Ryu), Max Planck Institute for Medical Research, Max Planck Society, ou_1497724              

Inhalt

einblenden:
ausblenden:
Schlagwörter: DEVBIO; MOLNEURO
 Zusammenfassung: Neurons that produce dopamine as a neurotransmitter constitute a heterogeneous group involved in the control of various behaviors and physiology. In mammals, dopaminergic neurons are found in distinct clusters mainly located in the ventral midbrain and the caudal forebrain [1]. Although much is known about midbrain dopaminergic neurons, development of diencephalic dopaminergic neurons is poorly understood. Here we demonstrate that Orthopedia (Otp) homeodomain protein is essential for the development of specific subsets of diencephalic dopaminergic neurons. Zebrafish embryos lacking Otp activity are devoid of dopaminergic neurons in the hypothalamus and the posterior tuberculum. Similarly, Otp-/- mouse [2, 3] embryos lack diencephalic dopaminergic neurons of the A11 group, which constitutes the diencephalospinal dopaminergic system. In both systems, Otp is expressed in the affected dopaminergic neurons as well as in potential precursor populations, and it might contribute to dopaminergic cell specification and differentiation. In fish, overexpression of Otp can induce ectopic tyrosine hydroxylase and dopamine transporter expression, indicating that Otp can specify aspects of dopaminergic identity. Thus, Otp is one of the few known transcription factors that can determine aspects of the dopaminergic phenotype and the first known factor to control the development of the diencephalospinal dopaminergic system.

Details

einblenden:
ausblenden:
Sprache(n): eng - English
 Datum: 2007-03-302006-11-292007-04-022007-05-032007-05-15
 Publikationsstatus: Erschienen
 Seiten: 8
 Ort, Verlag, Ausgabe: -
 Inhaltsverzeichnis: -
 Art der Begutachtung: Expertenbegutachtung
 Art des Abschluß: -

Veranstaltung

einblenden:

Entscheidung

einblenden:

Projektinformation

einblenden:

Quelle 1

einblenden:
ausblenden:
Titel: Current Biology
  Andere : Curr. Biol.
Genre der Quelle: Zeitschrift
 Urheber:
Affiliations:
Ort, Verlag, Ausgabe: London, UK : Cell Press
Seiten: - Band / Heft: 17 (10) Artikelnummer: - Start- / Endseite: 873 - 880 Identifikator: ISSN: 0960-9822
CoNE: https://pure.mpg.de/cone/journals/resource/954925579107