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  Cerebellar LTD and pattern recognition by Purkinje cells

Steuber, V., Mittmann, W., Hoebeek, F. E., Silver, R. A., De Zeeuw, C. I., Häusser, M., et al. (2007). Cerebellar LTD and pattern recognition by Purkinje cells. Neuron, 54(1), 121-136. doi:10.1016/j.neuron.2007.03.015.

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Genre: Journal Article
Alternative Title : Cerebellar LTD and pattern recognition by Purkinje cells

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Neuron_54_2007_121.pdf (Any fulltext), 2MB
 
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 Creators:
Steuber, Volker, Author
Mittmann, Wolfgang1, Author           
Hoebeek, Freek E., Author
Silver, R. Angus, Author
De Zeeuw, Chris I., Author
Häusser, Michael2, Author           
De Schutter, Erik, Author
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              
2Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497701              

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 Abstract: Many theories of cerebellar function assume that long-term depression (LTD) of parallel fiber (PF) synapses enables Purkinje cells to learn to recognize PF activity patterns. We have studied the LTD-based recognition of PF patterns in a biophysically realistic Purkinje-cell model. With simple-spike firing as observed in vivo, the presentation of a pattern resulted in a burst of spikes followed by a pause. Surprisingly, the best criterion to distinguish learned patterns was the duration of this pause. Moreover, our simulations predicted that learned patterns elicited shorter pauses, thus increasing Purkinje-cell output. We tested this prediction in Purkinje-cell recordings both in vitro and in vivo. In vitro, we found a shortening of pauses when decreasing the number of active PFs or after inducing LTD. In vivo, we observed longer pauses in LTD-deficient mice. Our results suggest a novel form of neural coding in the cerebellar cortex.

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Language(s): eng - English
 Dates: 2006-12-022006-05-202007-03-162007-04-042007-04-05
 Publication Status: Published in print
 Pages: 16
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 Table of Contents: -
 Rev. Type: Peer
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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 54 (1) Sequence Number: - Start / End Page: 121 - 136 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565