English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Topological reorganization of odor representations in the olfactory bulb

Yaksi, E., Judkewitz, B., & Friedrich, R. W. (2007). Topological reorganization of odor representations in the olfactory bulb. PLoS Biology, 5(7), 1453-1473. doi:10.1371/journal.pbio.0050178.

Item is

Basic

show hide
Genre: Journal Article
Alternative Title : Topological reorganization of odor representations in the olfactory bulb

Files

show Files
hide Files
:
PLoSBiol_5_2007_178e.pdf (Any fulltext), 3MB
 
File Permalink:
-
Name:
PLoSBiol_5_2007_178e.pdf
Description:
-
OA-Status:
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
OA-Status:
Description:
-
OA-Status:

Creators

show
hide
 Creators:
Yaksi, Emre1, Author           
Judkewitz, Benjamin1, Author           
Friedrich, Rainer W.1, Author           
Affiliations:
1Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society, ou_1497699              

Content

show
hide
Free keywords: -
 Abstract: Odors are initially represented in the olfactory bulb (OB) by patterns of sensory input across the array of glomeruli. Although activated glomeruli are often widely distributed, glomeruli responding to stimuli sharing molecular features tend to be loosely clustered and thus establish a fractured chemotopic map. Neuronal circuits in the OB transform glomerular patterns of sensory input into spatiotemporal patterns of output activity and thereby extract information about a stimulus. It is, however, unknown whether the chemotopic spatial organization of glomerular inputs is maintained during these computations. To explore this issue, we measured spatiotemporal patterns of odor-evoked activity across thousands of individual neurons in the zebrafish OB by temporally deconvolved two-photon Ca(2+) imaging. Mitral cells and interneurons were distinguished by transgenic markers and exhibited different response selectivities. Shortly after response onset, activity patterns exhibited foci of activity associated with certain chemical features throughout all layers. During the subsequent few hundred milliseconds, however, MC activity was locally sparsened within the initial foci in an odor-specific manner. As a consequence, chemotopic maps disappeared and activity patterns became more informative about precise odor identity. Hence, chemotopic maps of glomerular input activity are initially transmitted to OB outputs, but not maintained during pattern processing. Nevertheless, transient chemotopic maps may support neuronal computations by establishing important synaptic interactions within the circuit. These results provide insights into the functional topology of neural activity patterns and its potential role in circuit function.

Details

show
hide
Language(s): eng - English
 Dates: 2006-11-142007-05-072007-07-032007-07-03
 Publication Status: Published in print
 Pages: 21
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: PLoS Biology
  Other : PLoS Biol.
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Public Library of Science
Pages: - Volume / Issue: 5 (7) Sequence Number: - Start / End Page: 1453 - 1473 Identifier: ISSN: 1544-9173
CoNE: https://pure.mpg.de/cone/journals/resource/111056649444170