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  Motor learning requires purkinje cell synaptic potentiation through activation of AMPA-receptor subunit GluA3

Gutierrez-Castellanos, N., Da Silva-Matos, C. M., Zhou, K., Canto, C. B., Renner, M. C., Koene, L. M., et al. (2017). Motor learning requires purkinje cell synaptic potentiation through activation of AMPA-receptor subunit GluA3. Neuron, 93(2), 409-424. doi:10.1016/j.neuron.2016.11.046.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-B647-1 Version Permalink: http://hdl.handle.net/21.11116/0000-0000-28F3-1
Genre: Journal Article

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 Creators:
Gutierrez-Castellanos, Nicolas, Author
Da Silva-Matos, Carla M., Author
Zhou, Kuikui, Author
Canto, Cathrin B., Author
Renner, Maria C., Author
Koene, Linda M.C., Author
Ozyildirim, Ozgecan, Author
Sprengel, Rolf1, Author              
Kessels, Helmut W., Author
De Zeeuw, Chris I., Author
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: AMPA receptor; Epac; GluA3; LTP; Purkinje cell; cerebellum; learning; synapse
 Abstract: Accumulating evidence indicates that cerebellar long-term potentiation (LTP) is necessary for procedural learning. However, little is known about its underlying molecular mechanisms. Whereas AMPA receptor (AMPAR) subunit rules for synaptic plasticity have been extensively studied in relation to declarative learning, it is unclear whether these rules apply to cerebellum-dependent motor learning. Here we show that LTP at the parallel-fiber-to-Purkinje-cell synapse and adaptation of the vestibulo-ocular reflex depend not on GluA1- but on GluA3-containing AMPARs. In contrast to the classic form of LTP implicated in declarative memory formation, this form of LTP does not require GluA1-AMPAR trafficking but rather requires changes in open-channel probability of GluA3-AMPARs mediated by cAMP signaling and activation of the protein directly activated by cAMP (Epac). We conclude that vestibulo-cerebellar motor learning is the first form of memory acquisition shown to depend on GluA3-dependent synaptic potentiation by increasing single-channel conductance.

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Language(s): eng - English
 Dates: 2016-09-282016-01-082016-11-172016-12-292017-01-18
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Method: Peer
 Degree: -

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Title: Neuron
Source Genre: Journal
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Publ. Info: Cambridge, Mass. : Cell Press
Pages: - Volume / Issue: 93 (2) Sequence Number: - Start / End Page: 409 - 424 Identifier: ISSN: 0896-6273
CoNE: https://pure.mpg.de/cone/journals/resource/954925560565