English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
  Microstructured blood vessel surrogates reveal structural tropism of motile malaria parasites

Muthinja, M. J., Ripp, J., Hellmann, J. K., Haraszti, T., Dahan, N., Lemgruber, L., et al. (2017). Microstructured blood vessel surrogates reveal structural tropism of motile malaria parasites. Advanced Healthcare Materials, 6(6): 1601178, pp. 1-10. doi:10.1002/adhm.201601178.

Item is

Basic

show hide
Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-B68B-9 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002E-5DD3-4
Genre: Journal Article

Files

show Files
hide Files
:
AdvHealthcareMater_6_2017_1.pdf (Any fulltext), 4MB
 
File Permalink:
-
Name:
AdvHealthcareMater_6_2017_1.pdf
Description:
-
Visibility:
Restricted (Max Planck Institute for Medical Research, MHMF; )
MIME-Type / Checksum:
application/pdf
Technical Metadata:
Copyright Date:
-
Copyright Info:
-
License:
-

Locators

show
hide
Description:
-
Locator:
https://doi.org/10.1002/adhm.201601178 (Any fulltext)
Description:
-

Creators

show
hide
 Creators:
Muthinja, Mendi J., Author
Ripp, Johanna, Author
Hellmann, Janina K., Author
Haraszti, Tamas1, 2, Author              
Dahan, Noa, Author
Lemgruber, Leandro, Author
Battista, Anna, Author
Schütz, Lucas, Author
Fackler, Oliver T., Author
Schwarz, Ulrich S., Author
Spatz, Joachim P.1, 2, Author              
Frischknecht, Friedrich, Author
Affiliations:
1Cellular Biophysics, Max Planck Institute for Medical Research, Max Planck Society, ou_2364731              
2Biophysical Chemistry, Institute of Physical Chemistry, University of Heidelberg, 69120 Heidelberg, Germany, ou_persistent22              

Content

show
hide
Free keywords: PDMS pillar arrays; apicomplexa; blood vessels; gliding motility; sporozoites
 Abstract: Plasmodium sporozoites, the highly motile forms of the malaria parasite, are transmitted naturally by mosquitoes and traverse the skin to find, associate with, and enter blood capillaries. Research aimed at understanding how sporozoites select blood vessels is hampered by the lack of a suitable experimental system. Arrays of uniform cylindrical pillars can be used to study small cells moving in controlled environments. Here, an array system displaying a variety of pillars with different diameters and shapes is developed in order to investigate how Plasmodium sporozoites associate to the pillars as blood vessel surrogates. Investigating the association of sporozoites to pillars in arrays displaying pillars of different diameters reveals that the crescent-shaped parasites prefer to associate with and migrate around pillars with a similar curvature. This suggests that after transmission by a mosquito, malaria parasites may use a structural tropism to recognize blood capillaries in the dermis in order to gain access to the blood stream.

Details

show
hide
Language(s): eng - English
 Dates: 2016-12-172016-10-172017-01-242017-01-24
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Degree: -

Event

show

Legal Case

show

Project information

show

Source 1

show
hide
Title: Advanced Healthcare Materials
Source Genre: Journal
 Creator(s):
Affiliations:
Publ. Info: Wiley-VCH
Pages: - Volume / Issue: 6 (6) Sequence Number: 1601178 Start / End Page: 1 - 10 Identifier: ISSN: 2192-2640
CoNE: https://pure.mpg.de/cone/journals/resource/2192-2640