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  GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

Rozov, A., Sprengel, R., & Seeburg, P. H. (2012). GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice. Frontiers in Molecular Neuroscience, 5: 22, pp. 1-10. doi:10.3389/fnmol.2012.00022.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-D039-F Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-D03F-3
Genre: Journal Article
Alternative Title : GluA2-lacking AMPA receptors in hippocampal CA1 cell synapses: evidence from gene-targeted mice

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FrontMolNeurosci_5_2012_22_1.pdf (Any fulltext), 893KB
 
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 Creators:
Rozov, Andrei, Author
Sprengel, Rolf1, Author              
Seeburg, Peter H.1, Author              
Affiliations:
1Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society, ou_1497704              

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Free keywords: AMPA receptors, hippocampal CA1 cell synapses
 Abstract: The GluA2 subunit in heteromeric alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor channels restricts Ca(2+) permeability and block by polyamines, rendering linear the current-voltage relationship of these glutamate-gated cation channels. Although GluA2-lacking synaptic AMPA receptors occur in GABA-ergic inhibitory neurons, hippocampal CA1 pyramidal cell synapses are widely held to feature only GluA2 containing AMPA receptors. A controversy has arisen from reports of GluA2-lacking AMPA receptors at hippocampal CA3-to-CA1 cell synapses and a study contesting these findings. Here we sought independent evidence for the presence of GluA2-lacking AMPA receptors in CA1 pyramidal cell synapses by probing the sensitivity of their gated cation channels in wild-type (WT) mice and gene-targeted mouse mutants to philanthotoxin, a specific blocker of GluA2-lacking AMPA receptors. The mutants either lacked GluA2 for maximal philanthotoxin sensitivity, or, for minimal sensitivity, expressed GluA1 solely in a Q/R site-edited version or not at all. Our comparative electrophysiological analyses provide incontrovertible evidence for the presence in wild-type CA1 pyramidal cell synapses of GluA2-less AMPA receptor channels. This article is part of a Special Issue entitled "Calcium permeable AMPARs in synaptic plasticity and disease."

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Language(s): eng - English
 Dates: 2012-01-042012-02-112012-02-24
 Publication Status: Published online
 Pages: 10
 Publishing info: -
 Table of Contents: -
 Rev. Type: Peer
 Identifiers: eDoc: 664381
DOI: 10.3389/fnmol.2012.00022
URI: http://www.ncbi.nlm.nih.gov/pubmed/22375105
Other: 7817
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Title: Frontiers in Molecular Neuroscience
Source Genre: Journal
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Publ. Info: Lausanne, Switzerland : Frontiers Research Foundation
Pages: - Volume / Issue: 5 Sequence Number: 22 Start / End Page: 1 - 10 Identifier: ISSN: 1662-5099
CoNE: https://pure.mpg.de/cone/journals/resource/1662-5099