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  Molecular features of cellular reprogramming and development

Smith, Z. D., Sindhu, C., & Meissner, A. (2016). Molecular features of cellular reprogramming and development. Nature Reviews Molecular Cell Biology, 17(3), 139-154. doi:10.1038/nrm.2016.6.

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Item Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-DEA6-5 Version Permalink: http://hdl.handle.net/11858/00-001M-0000-002C-DEA7-3
Genre: Journal Article

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Smith.pdf (Publisher version), 795KB
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© 2016 Macmillan Publishers Limited, part of Springer Nature
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 Creators:
Smith, Zachary D.1, Author
Sindhu, Camille2, Author
Meissner, Alexander3, 4, Author              
Affiliations:
1Broad Institute of MIT and Harvard, Cambridge, Massachusetts 02142, USA, ou_persistent22              
2Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA, ou_persistent22              
3Dept. of Genome Regulation (Head: Alexander Meissner), Max Planck Institute for Molecular Genetics, Max Planck Society, ou_2379694              
4Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, Massachusetts 02138, USA, ou_persistent22              

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Free keywords: Differentiation Epigenetics Induced pluripotent stem cells Reprogramming
 Abstract: Differentiating somatic cells are progressively restricted to specialized functions during ontogeny, but they can be experimentally directed to form other cell types, including those with complete embryonic potential. Early nuclear reprogramming methods, such as somatic cell nuclear transfer (SCNT) and cell fusion, posed significant technical hurdles to precise dissection of the regulatory programmes governing cell identity. However, the discovery of reprogramming by ectopic expression of a defined set of transcription factors, known as direct reprogramming, provided a tractable platform to uncover molecular characteristics of cellular specification and differentiation, cell type stability and pluripotency. We discuss the control and maintenance of cellular identity during developmental transitions as they have been studied using direct reprogramming, with an emphasis on transcriptional and epigenetic regulation.

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Language(s): eng - English
 Dates: 2016-02-172016-03
 Publication Status: Published in print
 Pages: 16
 Publishing info: -
 Table of Contents: -
 Rev. Type: -
 Identifiers: DOI: 10.1038/nrm.2016.6
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Title: Nature Reviews Molecular Cell Biology
Source Genre: Journal
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Publ. Info: London, UK : Nature Pub. Group
Pages: - Volume / Issue: 17 (3) Sequence Number: - Start / End Page: 139 - 154 Identifier: ISSN: 1471-0072
CoNE: https://pure.mpg.de/cone/journals/resource/110985821000941